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Table 6 Differences in biological and clinical aging markers between miRNA-based patient clusters at inclusion

From: Age-related microRNAs in older breast cancer patients: biomarker potential and evolution during adjuvant chemotherapy

Aging/frailty parameter Statistic Patient cluster A Patient cluster B p-value
Calendar age N 43 45  
Mean ± SD 76.5 ± 5.2 73.8 ± 3.1 0.018
BALDUCCI
 Fit n/N (%) 9/43 (20.9%) 12/44 (27.3%)  
 Vulnerable n/N (%) 12/43 (27.9%) 16/44 (36.4%)  
 Frail n/N (%) 22/43 (51.1%) 16/44 (36.4%) 0.378
LOFS N 42 44  
Mean ± SD 6.9 ± 2.2 7.7 ± 1.7 0.119
G8-total N 43 45  
Mean ± SD 14.1 ± 1.8 14.2 ± 2.1 0.571
fTRST N 36 30  
Mean ± SD 2.3 ± 1.0 1.8 ± 0.9 0.046
Telomere length (T/S ratio) N 33 38  
Mean ± SD 0.67 ± 0.17 0.74 ± 0.28 0.423
IL-6 a (pg/mL) N 43 45  
Median (IQR) 4.3 (2.4; 6.4) 1.7 (1.0; 3.3) < 0.001
IL-10 (pg/mL) N 41 43  
Mean ± SD 0.26 ± 0.25 0.25 ± 0.30 0.528
IGF-1 (pg/mL) N 43 45  
Mean ± SD 73 ± 24 79 ± 24 0.308
TNFα (pg/mL) N 43 45  
Median (IQR) 1.5 (0.9; 2.3) 1.2 (0.7; 1.6) 0.032
MCP-1 (pg/mL) N 43 45  
Mean ± SD 197 ± 90 146 ± 57 < 0.001
RANTES (ng/mL) N 43 45  
Mean ± SD 52 ± 42 64 ± 47 0.179
  1. aFor IL-6 and TNFα, median and IQR was used instead of mean ± SD, to moderate the effect of outliers
  2. p-values < 0.05 are marked in bold