Age-related microRNAs in older breast cancer patients: biomarker potential and evolution during adjuvant chemotherapy

Table 2 Univariable association of microRNAs with chronological age and geriatric assessment parameters at inclusion

	Calendar age		Balducci frailty score (median)				LOFS (N = 87)		G8 (N = 89)		fTRST (N = 66)
Micro RNA^a	Spearman correlation	p-value	Fit (N = 21)	Vulnerable (N = 29)	Frail (N = 38)	p-value	Spearman correlation	p-value	Spearman correlation	p-value	Spearman correlation	p-value
miR-20a	−0.061	0.5693	0.38	0.16	0.54	0.577	0.023	0.8304	0.037	0.7289	−0.054	0.6685
miR-30b	−0.202	0.0578	0.14	0.14	0.10	0.829	0.086	0.4306	−0.057	0.5967	−0.065	0.6059
miR-34a	0.043	0.6867	−0.41	−0.21	0.00	0.711	− 0.039	0.7224	0.015	0.8918	0.090	0.4729
miR-106b	−0.211	0.0472	0.07	0.01	0.09	0.837	−0.040	0.7131	−0.014	0.8966	0.004	0.9755
miR-191	−0.144	0.1771	0.13	0.06	−0.22	0.080	0.223	0.0376	−0.008	0.9413	−0.167	0.1798
miR-301a	−0.285	0.0068	0.38	0.35	−0.05	0.037	0.257	0.0164	0.024	0.8215	−0.322	0.0084
miR-320b	0.186	0.0802	0.06	−0.15	− 0.10	0.575	− 0.037	0.7342	− 0.076	0.4793	0.056	0.6533
miR-374a	−0.212	0.0466	0.11	0.10	−0.23	0.163	0.308	0.0037	0.185	0.0823	−0.221	0.0747
miR-378a	0.030	0.7827	0.02	0.03	0.12	0.642	−0.161	0.1359	−0.095	0.3753	0.055	0.6585

p-values < 0.05 are marked in bold
^amiR-34a, miR-320b and miR-378a were previously shown to increase with aging; miR-20a, miR-30b, miR-106b, miR-191, miR-301a and miR-374a were previously shown to decrease with aging

ISSN: 1471-2407