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Table 2 Univariable association of microRNAs with chronological age and geriatric assessment parameters at inclusion

From: Age-related microRNAs in older breast cancer patients: biomarker potential and evolution during adjuvant chemotherapy

  Calendar age Balducci frailty score (median) LOFS (N = 87) G8 (N = 89) fTRST (N = 66)
Micro RNAa Spearman correlation p-value Fit (N = 21) Vulnerable (N = 29) Frail (N = 38) p-value Spearman correlation p-value Spearman correlation p-value Spearman correlation p-value
miR-20a −0.061 0.5693 0.38 0.16 0.54 0.577 0.023 0.8304 0.037 0.7289 −0.054 0.6685
miR-30b −0.202 0.0578 0.14 0.14 0.10 0.829 0.086 0.4306 −0.057 0.5967 −0.065 0.6059
miR-34a 0.043 0.6867 −0.41 −0.21 0.00 0.711 − 0.039 0.7224 0.015 0.8918 0.090 0.4729
miR-106b −0.211 0.0472 0.07 0.01 0.09 0.837 −0.040 0.7131 −0.014 0.8966 0.004 0.9755
miR-191 −0.144 0.1771 0.13 0.06 −0.22 0.080 0.223 0.0376 −0.008 0.9413 −0.167 0.1798
miR-301a −0.285 0.0068 0.38 0.35 −0.05 0.037 0.257 0.0164 0.024 0.8215 −0.322 0.0084
miR-320b 0.186 0.0802 0.06 −0.15 − 0.10 0.575 − 0.037 0.7342 − 0.076 0.4793 0.056 0.6533
miR-374a −0.212 0.0466 0.11 0.10 −0.23 0.163 0.308 0.0037 0.185 0.0823 −0.221 0.0747
miR-378a 0.030 0.7827 0.02 0.03 0.12 0.642 −0.161 0.1359 −0.095 0.3753 0.055 0.6585
  1. p-values < 0.05 are marked in bold
  2. amiR-34a, miR-320b and miR-378a were previously shown to increase with aging; miR-20a, miR-30b, miR-106b, miR-191, miR-301a and miR-374a were previously shown to decrease with aging