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Table 5 Univariate and multivariate analyses to identify predictors for time to hepatotoxicity related to erlotinib administration

From: Risk factors for erlotinib-induced hepatotoxicity: a retrospective follow-up study

Characteristics Unadjusted HR (95% CI) Adjusted HR (95% CI)
Male 0.876 (0.530–1.448) 1.045 (0.579–1.886)
Age ≥ 65 1.314 (0.797–2.169) 1.265 (0.764–2.095)
BSA ≥ 1.6a 0.795 (0.483–1.309) 0.771 (0.431–1.377)
Liver metastasis 1.897 (1.100–3.275)** 2.052 (1.179–3.572)*
CYP3A4 inducer 2.017 (0.918–4.433) 2.318 (1.029–5.221)*
  1. For multivariate analysis, factors with p < 0.1 in the univariate analysis were included in addition to sex, age and BSA
  2. BSA body surface are
  3. aThere was 1 missing data for BSA
  4. *P < 0.05, **P < 0.01