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Table 5 Univariate and multivariate analyses to identify predictors for time to hepatotoxicity related to erlotinib administration

From: Risk factors for erlotinib-induced hepatotoxicity: a retrospective follow-up study

Characteristics

Unadjusted HR (95% CI)

Adjusted HR (95% CI)

Male

0.876 (0.530–1.448)

1.045 (0.579–1.886)

Age ≥ 65

1.314 (0.797–2.169)

1.265 (0.764–2.095)

BSA ≥ 1.6a

0.795 (0.483–1.309)

0.771 (0.431–1.377)

Liver metastasis

1.897 (1.100–3.275)**

2.052 (1.179–3.572)*

CYP3A4 inducer

2.017 (0.918–4.433)

2.318 (1.029–5.221)*

  1. For multivariate analysis, factors with p < 0.1 in the univariate analysis were included in addition to sex, age and BSA
  2. BSA body surface are
  3. aThere was 1 missing data for BSA
  4. *P < 0.05, **P < 0.01
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BMC Cancer

ISSN: 1471-2407

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