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Table 3 Univariate and multivariate Cox proportional hazards regression for overall survival

From: A molecular and staging model predicts survival in patients with resected non-small cell lung cancer

Variables Category Univariate Multivariate
HR 95%CI P-value HR 95%CI P-value
Age (years) < 60 1.00      
≥60 1.25 0.96–3.18 0.105    
Gender Male 1.00      
Female 1.05 0.80–1.43 0.849    
Smoking status Never-smoker 1.00      
Ever-smoker 1.03 0.84–1.67 0.918    
TNM stage I 1.00    1.00   
II 1.30 1.12–2.39 0.003 1.34 1.15–2.46 0.001
III 2.21 1.34–3.49 <0.001 2.28 1.42–3.56 <0.001
Grade Well-differentiated 1.00    1.00   
Moderately-differentiated 1.23 1.90–2.31 0.006 1.31 1.18–2.43 0.004
Poorly-differentiated 1.80 1.48–2.95 <0.001 1.81 1.47–2.92 <0.001
Histology Squamous cell carcinoma 1.00      
Adenocarcinoma 0.91 0.75–1.38 0.239    
Adjuvant therapy No 1.00    1.00   
Yes 0.89 0.77–0.94 0.036 0.91 0.81–1.03 0.062
TPX2 Negative 1.00    1.00   
Positive 1.65 1.21–2.37 <0.001 1.61 1.14–2.26 <0.001
MMP12 Negative 1.00    1.00   
Positive 1.72 1.30–2.26 <0.001 1.73 1.28–2.54 <0.001