Table 3 Univariate and multivariate Cox proportional hazards regression for overall survival
From: A molecular and staging model predicts survival in patients with resected non-small cell lung cancer
Variables | Category | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|
HR | 95%CI | P-value | HR | 95%CI | P-value | ||
Age (years) | < 60 | 1.00 | |||||
≥60 | 1.25 | 0.96–3.18 | 0.105 | ||||
Gender | Male | 1.00 | |||||
Female | 1.05 | 0.80–1.43 | 0.849 | ||||
Smoking status | Never-smoker | 1.00 | |||||
Ever-smoker | 1.03 | 0.84–1.67 | 0.918 | ||||
TNM stage | I | 1.00 | 1.00 | ||||
II | 1.30 | 1.12–2.39 | 0.003 | 1.34 | 1.15–2.46 | 0.001 | |
III | 2.21 | 1.34–3.49 | <0.001 | 2.28 | 1.42–3.56 | <0.001 | |
Grade | Well-differentiated | 1.00 | 1.00 | ||||
Moderately-differentiated | 1.23 | 1.90–2.31 | 0.006 | 1.31 | 1.18–2.43 | 0.004 | |
Poorly-differentiated | 1.80 | 1.48–2.95 | <0.001 | 1.81 | 1.47–2.92 | <0.001 | |
Histology | Squamous cell carcinoma | 1.00 | |||||
Adenocarcinoma | 0.91 | 0.75–1.38 | 0.239 | ||||
Adjuvant therapy | No | 1.00 | 1.00 | ||||
Yes | 0.89 | 0.77–0.94 | 0.036 | 0.91 | 0.81–1.03 | 0.062 | |
TPX2 | Negative | 1.00 | 1.00 | ||||
Positive | 1.65 | 1.21–2.37 | <0.001 | 1.61 | 1.14–2.26 | <0.001 | |
MMP12 | Negative | 1.00 | 1.00 | ||||
Positive | 1.72 | 1.30–2.26 | <0.001 | 1.73 | 1.28–2.54 | <0.001 | |