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Table 2 Association between age, BMI, BSA, pathological grade, and molecular biomarkers with PIPNa

From: Risk factors for paclitaxel-induced peripheral neuropathy in patients with breast cancer

  PIPN Incidence PIPN Severity
RRb (95%CI), P value B (95% CI), P value
Age (year) 1.50 (1.07 to 1.87), .024 .61 (−.05 to 1.27), .071
Body mass index (BMI, kg/m2) 1.44 (.77 to 1.98), .208 1.28 (.16 to 2.41), .025
Body surface area (BSA, m2) 2.28 (1.14–2.38), .035 3.88 (.93 to 6.82), .010
Progesterone receptor (+ vs.-) 1.88 (1.19–2.22), .015 1.54 (.33–2.74), .012
  1. In multivariate analysis, age and progesterone receptor were shown as independent risk factors for incidence of PIPN, RR: 1.57, 95% CI: (1.03 to 1.98), P = .037 & RR: 1.85, 95% CI: (1.07 to 2.23), P = .034 respectively. Additionally, progesterone receptor was the only independent risk factor for severity of PIPN, B: 1.24, 95% CI: (.01 to 2.47), P = .048
  2. aPaclitaxel-induced peripheral neuropathy
  3. bRelative risk