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Table 2 Factors associated with chemotherapy-induced Dose-Limiting Toxicities (DLT)

From: Dynapenia could predict chemotherapy-induced dose-limiting neurotoxicity in digestive cancer patients

Characteristicsa DLTs No DLT Univariate analysis
(n = 22) (n = 23) p value
Maximum handgrip strength, mean ± SD 26.1 ± 7.2 31.2 ± 10.8 0.21
Dynapenia 7 (31.8) 4 (17.4) 0.62
Age, mean ± 66.2 ± 13.5 66.3 ± 11.4 0.53
ECOG PS    0.90
 0 6 (27.3) 6 (26.1)  
 1 16 (72.7) 15 (65.2)  
 2 0 (0) 2 (8.7)  
mGPSb    0.12
0, N (%) 11 (64.7) 6 (35.3)  
1, N (%) 7 (41.2) 10 (58.8)  
2, N (%) 2 (40.0) 3 (60.0)  
 0 11 (55.0) 6 (31.6)  
 1 7 (35.0) 10 (52.6)  
 2 2 (10.0) 3 (15.8)  
Primary tumor location    0.21
 Colon and rectum 12 (57.1) 10 (45.4)  
 Esophagus 1 (4.8) 2 (9.1)  
 Stomach 1 (4.8) 4 (18.2)  
 Biliary tract 1 (4.8) 0 (0)  
 Pancreas 6 (28.6) 3 (13.6)  
 Small intestine 0 (0) 1 (4.5)  
 Neuroendocrine tumor 0 (0) 2 (9.1)  
Stage 22 (48.8) 23 (51.2) 0.77
Local, N (%) 11 (55.0) 9 (45.0)  
Locally advanced, N (%) 3 (50.0) 3 (50.0)  
Metastatic, N (%) 8 (42.1) 11 (57.9)  
 Local 11 (50) 9 (39.1)  
 Locally advanced 3 (13.6) 3 (13.0)  
 Metastatic 8 (36.4) 11 (47.8)  
BMI, mean ± SD, kg/m2 22.7 ± 3.9 23.8 ± 4.3 0.64
BMI categories    0.36
 Malnutrition c 5 (22.7) 2 (8.7)  
 Normal 11 (50.0) 13 (56.5)  
 Overweightd 6 (27.3) 8 (34.8)  
  1. SD standard deviation, BMI body mass index, mGPS modified Glasgow Prognostic Score, ECOG PS Eastern Cooperative Oncology Group Criteria Performance Status
  2. aData are expressed as No (%) unless otherwise indicated
  3. b6 missing data
  4. cmalnutrition was defined as BMI < 21 kg/m2 in patients aged more than 70 years old and BMI < 18.5 kg/m2 in patients aged less than 70 years old
  5. doverweight was defined as BMI > 25 kg/m2