Table 2 Factors associated with chemotherapy-induced Dose-Limiting Toxicities (DLT)
Characteristicsa | DLTs | No DLT | Univariate analysis |
|---|---|---|---|
(n = 22) | (n = 23) | p value | |
Maximum handgrip strength, mean ± SD | 26.1 ± 7.2 | 31.2 ± 10.8 | 0.21 |
Dynapenia | 7 (31.8) | 4 (17.4) | 0.62 |
Age, mean ± | 66.2 ± 13.5 | 66.3 ± 11.4 | 0.53 |
ECOG PS | 0.90 | ||
0 | 6 (27.3) | 6 (26.1) | |
1 | 16 (72.7) | 15 (65.2) | |
2 | 0 (0) | 2 (8.7) | |
mGPSb | 0.12 | ||
0, N (%) | 11 (64.7) | 6 (35.3) | |
1, N (%) | 7 (41.2) | 10 (58.8) | |
2, N (%) | 2 (40.0) | 3 (60.0) | |
0 | 11 (55.0) | 6 (31.6) | |
1 | 7 (35.0) | 10 (52.6) | |
2 | 2 (10.0) | 3 (15.8) | |
Primary tumor location | 0.21 | ||
Colon and rectum | 12 (57.1) | 10 (45.4) | |
Esophagus | 1 (4.8) | 2 (9.1) | |
Stomach | 1 (4.8) | 4 (18.2) | |
Biliary tract | 1 (4.8) | 0 (0) | |
Pancreas | 6 (28.6) | 3 (13.6) | |
Small intestine | 0 (0) | 1 (4.5) | |
Neuroendocrine tumor | 0 (0) | 2 (9.1) | |
Stage | 22 (48.8) | 23 (51.2) | 0.77 |
Local, N (%) | 11 (55.0) | 9 (45.0) | |
Locally advanced, N (%) | 3 (50.0) | 3 (50.0) | |
Metastatic, N (%) | 8 (42.1) | 11 (57.9) | |
Local | 11 (50) | 9 (39.1) | |
Locally advanced | 3 (13.6) | 3 (13.0) | |
Metastatic | 8 (36.4) | 11 (47.8) | |
BMI, mean ± SD, kg/m2 | 22.7 ± 3.9 | 23.8 ± 4.3 | 0.64 |
BMI categories | 0.36 | ||
Malnutrition c | 5 (22.7) | 2 (8.7) | |
Normal | 11 (50.0) | 13 (56.5) | |
Overweightd | 6 (27.3) | 8 (34.8) |