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Table 1 Baseline characteristics (n = 45)

From: Dynapenia could predict chemotherapy-induced dose-limiting neurotoxicity in digestive cancer patients

Characteristicsa

Value

Age, mean ± SD

66.2 ± 12.3

Sex

 Male

21 (46.7)

 Female

24 (53.3)

Body Mass Index, mean ± SD, kg/m2

23.2 ± 4.1

BMI categories, No. (%)

 Malnutrition b

7 (15.6)

 Normal

24 (53.3)

 Overweight c

14 (31.1)

ECOG PS, No. (%)

 0

12 (26.7)

 1

31 (68.9)

 2

2 (4.4)

mGPSd, No. (%)

 0

17 (43.6)

 1

17(43.6)

 2

5 (12.8)

Hospitalizations number, median [range]

10 [0–18]

Follow-up, median [range], days

167 [0–189]

Primary tumor location, No. (%)

 Colon and rectum

22 (48.9)

 Esophagus

3 (6.7)

 Stomach

5 (11.1)

 Biliary tract

1 (2.2)

 Pancreas

9 (20.0)

 Small intestine

1 (2.2)

 Neuroendocrine tumor

2 (4.4)

 Unknown

2 (4.4)

Stage, No. (%)

 Local

20 (44.4)

 Locally advanced

6 (13.3)

 Metastatic

19 (42.2)

Type of treatment, No. (%)

 Chemotherapy

38 (84.4)

 Chemotherapy and biotherapy

7 (15.6)

Chemotherapy protocol, No. (%)

 5FU + OXALIPLATIN

22 (48.9)

 5FU + IRINOTECAN + OXALIPLATIN

7 (15.6)

 5FU alone

6 (13.3)

 GEMCITABINE

5 (11.1)

 5FU-DACARBAZINE

2 (4.4)

 5FU + IRINOTECAN

1 (2.2)

 GEMCITABINE + OXALIPLATIN

1 (2.2)

 VP16 + CISPLATINE

1 (2.2)

Neurotoxic chemotherapy e, No. (%)

31 (68.9)

Biotherapy protocol, No. (%)

 BEVACIZUMAB

6/7 (85.7)

 CETUXIMAB

1/7 (14.3)

Dynapenia, No. (%)

11 (24.4)

  1. SD standard deviation, BMI body mass index, mGPS modified Glasgow Prognostic Score, ECOG PS Eastern Cooperative Oncology Group Criteria Performance Status
  2. aData are expressed as No (%) unless otherwise indicated
  3. bmalnutrition was defined as BMI < 21 kg/m2 in patients aged more than 70 years old and BMI < 18.5 kg/m2 in patients aged less than 70 years old
  4. coverweight was defined as BMI > 25 kg/m2
  5. d6 missing data
  6. eneurotoxic regimens: 5FU + IRINOTECAN+OXALIPLATIN, 5FU + OXALIPLATIN,GEMCITABINE + OXALIPLATIN; VP16-CISPLATINE