Impact of the epidermal growth factor receptor mutation status on the prognosis of recurrent adenocarcinoma of the lung after curative surgery

Table 4 Multivariate Cox’s Proportional Hazard Regression Model for PRS

Variable	Univariate analysis	Multivariate analysis
Variable	p value	HR	95% CI	p value
Age (> 65)	0.014	1.63	1.11–2.38	0.012
Gender (Male)	0.178
Smoking history	0.008	1.38	0.93–2.05	0.113
Pathological T factor	< 0.001	1.07	0.80–1.45	0.638
Pathological N factor	0.831
Pathological stage	0.684
Vessel invasion	0.722
Lymphatic invasion	0.787
Pleural invasion	0.659
Systemic recurrence (vs. locoregional)	0.072
EGFR mutation (+/−)	0.360
Administration of EGFR - TKI	< 0.001	0.60	0.40–0.89	0.012
Recurrence interval (24 < vs 24≥)	0.017	1.35	0.91–2.01	0.142

PRS post-relapse survival, EGFR epidermal growth factor receptor, TKI tyrosine kinase inhibitor, HR Hazards ratio, CI Confidence interval

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