Fig. 5

Comparison of DNA damage response gene expression in prostate cancer cell lines. a Venn diagram of differentially expressed DNA repair genes in LNCaP, VCaP, and PC3-AR cell line models. A total of 450 expert-curated DNA damage repair genes were assessed for androgen-mediated expression changes (2 nM R1881) using the following cut-offs: > 2-fold or < 0.5-fold; adj. p ≤ 0.05. LNCaP and VCaP treatments were conducted for 24 h while PC3-AR data was taken from a 12 h treatment. b Gene modules detected from WGCNA of RNA-sequencing. Positive (red) and negative (blue) gene expression correlations were significantly related to androgen treated. c Eigengene plots for gene modules I, II, XIV, and XV where gene sets were significantly associated with androgen treatment. Gene lists can be found in Additional file 7: Table S5