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Table 1 Blood cancer cell lines carry nonproductive BCR/TCR in either both alleles or the only expressed allele

From: Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines

  Cell lines Reads Fraction % V genes D genes J genes CDR3 Sequences
B-ALL NALM-19 425 36.08 IGHV1-3 IGHD6-6 IGHJ4 CARDRV*QL_PPPLRDYW
MHH-CALL-4 214 14.33 TRAV8-2 TRAJ8 CVVGL_QKLVF
163 10.92 IGHV2-26 IGHD2-21 IGHJ5 CARIRPRAVR_CGSP*GPDPW
KASUMI-2 3491 60.82 IGLV1-40 IGLJ3 CQSYD_AGVF
MUTZ-5 1632 76.30 IGLV2-34 IGLJ2 CSSYA_HLVVF
REH 100 16.21 IGHV3-15 IGHD3-10 IGHJ6 CTTGMVRGVI_YYYYGMDVW
RS4;11 361 26.05 IGHV6-1 IGHD1-20 IGHJ4 CAREP*LELFDYW
241 17.39 IGHV3-20 IGHD2-8 IGHJ5 CARD*SRY*W_VCYTDWFDPW
173 12.48 IGLV11-55 IGLJ7 CAMG_PQF
36 2.60 IGLV4-3 IGLJ3 CGESHTIDG_SRLRFWVF
NALM-6 15670 74.70 IGLV2-14 IGLJ7 CSSYTSS_ALGAVF
2479 11.82 IGLV4-3 IGLJ3 CGESHTIDGQ_RLQAPGGVF
2229 10.63 IGHV1-69 IGHD3-10 IGHJ6 CARDRRGEWPPSDYYYYYMDVW
T-ALL KE-37 656 56.21 TRBV3-2 TRBD1 TRBJ1-5 CASSQDSGTG_RVGNQPQHF
ALL-SIL 2364 51.42 TRGV7 TRGJ1 CATWGSG_YYKKLF
909 19.77 TRBV18 TRBD1 TRBJ2-1 CASSPMEK_GHKGEQFF
482 10.49 TRBV7-9 TRBD1 TRBJ2-7 CASSLDT_WYEQYF
221 4.81 TRGV9 TRGJ1 CALWR*_YYKKLF
86 1.87 TRDV2 TRDJ1 CACDK_DKLIF
MOLT-3 2913 6.95 TRBV10-3 TRBJ2-5 CAISEPTG_SEETQYF
231 0.55 TRAV1-1 TRAJ33 CAVRDHPW_SNYQLIW
97 0.23 TRAV1-1 TRAJ24 CAVKMEQ_WGKLQF
B cell lymphoma unspecified JM1 10946 48.32 IGLV3-1 IGLJ6 CQAWD_QPNVF
7877 34.78 IGLV3-10 IGLJ6 CYSTDSS_VIIANVF
1135 5.01 IGLV8-61 IGLJ7 CV_VF
HT 18074 89.54 IGKV3-11 IGKJ5 CQQRTNWPITF
1488 7.37 IGHV3-53 IGHD1-1 IGHJ4 CARASFAT_*LYFDSW
Blast phase CML B-ALL# BV-173 764 57.83 IGHV3-21 IGHD2-15 IGHJ3 CASQIL*WW*_PYRGAFDIW
157 11.88 IGKV2-29 IGKJ3 *MQGIH_SSLFTF
35 2.65 TRAV8-7 TRAJ19 CAGADRLQTGMRGAF
DLBCL Toledo 11815 58.54 IGLV2-14 IGLJ7 CSSYTS_QHSVF
6830 33.84 IGLV3-21 IGLJ6 CQVWDSS_*SPNVF
316 1.57 IGLV8-61 IGLJ7 CV_VF
  1. Asterisks “*” indicate stop codon; underscores “_” indicate out of frame CDR3 translation
  2. # BV-173 is also been regarded as an B cell precursor ALL cell lines [47] despite its original establishment from a patient with blast phase CML [48] (https://www.dsmz.de/catalogues/details/culture/ACC-20.html)