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Table 1 List of acceptable chemotherapy regimens

From: Febrile neutropenia (FN) occurrence outside of clinical trials: occurrence and predictive factors in adult patients treated with chemotherapy and an expected moderate FN risk. Rationale and design of a real-world prospective, observational, multinational study

Cancer type Regimen and Dosing
Bladder cancer M-VAC
Interval between cycles: 4 weeks
Cisplatin: 70 mg/m2
Doxorubicin: 30 mg/m2
Vinblastine: 3 mg/m2
Methotrexate: 90 mg/m2
Breast cancer AC
Interval between cycles: 3 weeks
Cyclophosphamide: 600 mg/m2
Doxorubicin: 60 mg/m2
AC → P (sequential regimen) for the P (paclitaxel) cycles
Interval between cycles: 3 weeks
Paclitaxel: 175 mg/m2
AC → T (sequential regimen) for the T (docetaxel) cycles
Variant 1: AC → T
Interval between cycles: 4 weeks
Docetaxel: 100 mg/m2
Variant 2: AC → T
Interval between cycles: 1 week
Docetaxel: 35 mg/m2
AV
Interval between cycles: 3 weeks
Doxorubicin: 50 mg/m2
Vinolrebine: 50 mg/m2
CAPE-T
Interval between cycles: 3 weeks
Capecitabine: 35000 mg/m2
Docetaxel: 75 mg/m2
CMF
Interval between cycles: 4 weeks
Cyclophosphamide: 1400 mg/m2
Fluorouracil: 1200 mg/m2
Methotrexate: 80 mg/m2
EC
Interval between cycles: 3 weeks
Cyclophosphamide: 600 mg/m2
Epidoxorubicin: 100 mg/m2
FEC → T (sequential regimen) for the T (docetaxel) cycles only
Interval between cycles: 3 weeks
Docetaxel: 100 mg/m2
FEC
Interval between cycles: 4 weeks
Cyclophosphamide: 1050 mg/m2
Epirubicin: 120 mg/m2
Fluorouracil: 1000 mg/m2
P
Interval between cycles: 3 weeks
Paclitaxel: 250 mg/m2
EC → T (sequential regimen) for the T (docetaxel) cycles
Interval between cycles: 3 weeks
Docetaxel: 100 mg/m2
T
Interval between cycles: 3 weeks
Docetaxel: 100 mg/m2
TC
Interval between cycles: 3 weeks
Cyclophosphamide: 600 mg/m2
Docetaxel: 75 mg/m2
Cervical cancer CDDP/PACLI
Interval between cycles: 3 weeks
Cisplatin: 50─75 mg/m2
Paclitaxel: 135 mg/m2
CDDP/TOPOTECAN
Interval between cycles: 3 weeks
Cisplatin: 50 mg/m2
Topotecan: 2.25 mg/m2
IRINOTECAN
Interval between cycles: 6 weeks
Irinotecan: 500 mg/m2
TOPOTECAN
Interval between cycles: 4 weeks
Topotecan: 7.5 mg/m2
Colorectal cancer 5FU/LEUCO
Interval between cycles: 4 weeks
Fluorouracil: 2125 mg/m2
Leucovorin: 100 mg/m2
FOLFIRI
Variant 1: FOLFIRI
Interval between cycles: 2 weeks
Fluorouracil: 2000─2400 mg/m2
Irinotecan: 180 mg/m2
Leucovorin: 200─400 mg/m2
Variant 2: FOLFIRI
Interval between cycles: 1 week
Fluorouracil: 2300 mg/m2
Irinotecan: 80 mg/m2
Variant 3: FOLFIRI
Interval between cycles: 2 weeks
Fluorouracil: 2000 mg/m2
Irinotecan: 180 mg/m2
FOLFOX
Interval between cycles: 2 weeks
Fluorouracil: 1600 mg/m2
Leucovorin: 200 mg/m2
Oxaliplatin: 85 mg/m2
Gastric cancer CDDP/IRINO
Interval between cycles: 3 weeks
Cisplatin: 60 mg/m2
Irinotecan: 130 mg/m2
DOCE/IRINO
Interval between cycles: 3 weeks
Docetaxel: 30 mg/m2
Irinotecan: 140 mg/m2
ECF
Interval between cycles: 3 weeks
Epirubicin: 50 mg/m2
Cisplatin: 60 mg/m2
Fluorouracil: 200 mg/m2
ECX
Interval between cycles: 3 weeks
Epirubicin: 50 mg/m2
Cisplatin: 60 mg/m2
Capecitabin: 26250 mg/m2
EOF
Interval between cycles: 3 weeks
Epirubicin: 50 mg/m2
Oxaliplatin: 130 mg/m2
Fluorouracil: 200 mg/m2
EOX
Interval between cycles: 3 weeks
Epirubicin: 50 mg/m2
Oxaliplatin: 130 mg/m2
Capecitabine: 26250 mg/m2
FOLFOX
Interval between cycles: 2 weeks
Fluorouracil: 3400 mg/m2
Oxaliplatin: 100 mg/m2
Germ cell tumors BEP followed by EP
Interval between cycles: 3 weeks
Bleomycin: 90 U
Cisplatin: 100 mg/m2
Etoposide: 500 mg/m2
CDDP/VP16
Interval between cycles: 3 weeks
Cisplatin: 100 mg/m2
Etoposide: 300─500 mg/m2
Hodgkin lymphoma Stanford V
Interval between cycles: 4 weeks
Bleomycin: 10 U
Doxorubicin: 50 mg/m2
Etoposide: 120 mg/m2
Mechlorethamine: 6 mg/m2
Vinblastine: 12 mg/m2
Vincristine: 2.8 mg/m2
Non-Hodgkin lymphoma ACOD
Interval between cycles: 3 weeks
Cyclophosphamide: 1000 mg/m2
Doxorubicin: 50 mg/m2
Vincristine: 2.4 mg/m2
CCOP
Interval between cycles: 4 weeks
Cyclophosphamide: 750 mg/m2
Liposomal Doxorubicin: 30 mg/m2
Vincristine: 2 mg/m2
CHOP
Interval between cycles: 2 or 3 weeks
Cyclophosphamide: 750–1200 mg/m2
Doxorubicin: 50–75 mg/m2
Vincristine: 1.4 mg/m2
DA-EPOCH
Interval between cycles: 3 weeks
Cyclophosphamide: 3750 mg/m2
Doxorubicin: 40 mg/m2
Etoposide: 200 mg/m2
Vincristine: 1.6 mg/m2
GMOX-R (with rituximab)
Interval between cycles: 2 or 3 weeks
Gemcitabine: 1000 mg/m2
Oxaliplatine: 100 mg/m2
GC
Variant 1:
Interval between cycles: 4 weeks
Cisplatin: 100 mg/m2
Gemcitabine: 3000 mg/m2
Variant 2:
Interval between cycles: 3 weeks
Cisplatin: 75 mg/m2
Gemcitabine: 2000 mg/m2
MEGACHOP (with rituximab)
Interval between cycles: 3 weeks
Cyclophosphamide: 1200 mg/m2
Doxorubicin: 75 mg/m2
Vincristine: 2 mg/m2
RFM (with rituximab)
Interval between cycles: 4 weeks
Fludarabine: 75 mg/m2
Mitoxantrone: 10 mg/m2
Non-small cell lung cancer Carbo/PACLI
Interval between cycles: 3 weeks
Carboplatin: 6 AUC
Paclitaxel: 200 mg/m2
CDDP/DOCE
Interval between cycles: 3 weeks
Cisplatin: 75 mg/m2
Docetaxel: 75 mg/m2
CDDP/PACLI
Interval between cycles: 3 weeks
Cisplatin: 50─75 mg/m2
Paclitaxel: 135 mg/m2
CDDP/VNR
Variant 1: CDDP/VNR
Interval between cycles: 4 weeks
Cisplatin: 100 mg/m2
Vinorelbine: 100 mg/m2
Variant 2: CDDP/VNR
Interval between cycles: 4 weeks
Cisplatin: 100 mg/m2
Vinorelbine: 120 mg/m2
CDDP/VP16
Interval between cycles: 3 weeks
Cisplatin: 100 mg/m2
Etoposide: 300─500 mg/m2
VIG
Variant 1: VIG
Interval between cycles: 3 weeks
Gemcitabine: 1800 mg/m2
Ifosfamide: 3000 mg/m2
Navelbine: 45 mg/m2
Variant 2: VIG
Interval between cycles: 3 weeks
Gemcitabine: 2000 mg/m2
Ifosfamide: 3000 mg/m2
Navelbine: 50 mg/m2
T
Interval between cycles: 3 weeks
Docetaxel: 75 mg/m2
Occult primary adenocarcinoma DOCE/GEMCI
Interval between cycles: 3 weeks
Docetaxel: 75 mg/m2
Gemcitabine: 2000 mg/m2
Esophageal cancer CDDP/IRINO
Interval between cycles: 3 weeks
Cisplatin: 60 mg/m2
Irinotecan: 130 mg/m2
ECF
Interval between cycles: 3 weeks
Epirubicin: 50 mg/m2
Cisplatin: 60 mg/m2
Fluorouracil: 200 mg/m2
ECX
Interval between cycles: 3 weeks
Epirubicin: 50 mg/m2
Cisplatin: 60 mg/m2
Capecitabin: 26250 mg/m2
EOF
Interval between cycles: 3 weeks
Epirubicin: 50 mg/m2
Oxaliplatin: 130 mg/m2
Fluorouracil: 200 mg/m2
EOX
Interval between cycles: 3 weeks
Epirubicin: 50 mg/m2
Oxaliplatin: 130 mg/m2
Capecitabine: 26250 mg/m2
Ovarian cancer CARBO/DOCE
Interval between cycles: 3 weeks
Carboplatin: 5 AUC
Docetaxel: 75 mg/m2
CARBO/PLACLI → TOPOTECAN (sequential treatment) only for the topotecan cycles
Interval between cycles: 3 weeks
Topotecan: 7.5 mg/m2
TOPOTECAN
Interval between cycles: 3 weeks
Topotecan: 7.5 mg/m2
Pancreatic cancer GEMCI/IRINO
Interval between cycles: 3 weeks
Gemcitabine: 2000 mg/m2
Irinotecan: 300 mg/m2
Prostate cancer CABAZITAXEL
Interval between cycles: 3 weeks
Cabazitaxel: 25 mg/m2
T
Interval between cycles: 3 weeks
Docetaxel: 75─100 mg/m2
Small-cell lung cancer CARBO/VP16
Interval between cycles: 3 weeks
Carboplatin: 300 mg/m2
Etoposide: 900 mg/m2
CAV
Interval between cycles: 3 weeks
Cyclophosphamide: 750 mg/m2
Doxorubicin: 40 mg/m2
Vincristine: 1.3 mg/m2
CDE
Interval between cycles: 3 weeks
Cyclophosphamide: 1000 mg/m2
Doxorubicin: 45 mg/m2
Etoposide: 300 mg/m2
CDDP/VP16
Interval between cycles: 3 weeks
Cisplatin: 100 mg/m2
Etoposide: 300─500 mg/m2
Soft tissue sarcoma T
Interval between cycles: 3 weeks
Docetaxel: 100 mg/m2
Uterine cancer T
Interval between cycles: 3 weeks
Docetaxel: 100 mg/m2