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Table 2 Factors Associated With Secondary Primary CRC (SPCRC) Risk Among Survivors of colorectal cancer

From: Second primary colorectal cancer after the initial primary colorectal cancer

Cancer type Univariate Cox Regression Multivariate Cox Regression
HR 95% CI P HR 95% CI P
History of IPCRC    < 0.001    < 0.001
 RCC 1.000 1.000   1.000 1.000  
 LCC 1.362 1.264–1.468 < 0.001 1.369 1.269–1.477 < 0.001
 Rectosigmoid colon 1.031 0.951–1.118 < 0.454 1.090 1.003–1.184 0.041
Age at diagnosis    < 0.001    < 0.001
  < 40 1.000 1.000   1.000 1.000  
 40–49 1.026 0.800–1.315 0.839 1.018 0.794–1.305 0.890
 50–59 1.027 0.816–1.293 0.820 0.954 0.799–1.268 0.954
 60–69 1.352 1.082–1.691 0.008 1.342 1.073–1.679 0.010
 70–79 1.516 1.215–1.892 < 0.001 1.541 1.234–1.925 < 0.001
  > 80 1.257 1.003–1.576 0.047 1.339 1.066–1.680 0.012
Sex
 Female vs. Male 0.928 0.870–0.989 0.021 0.930 0.871–0.992 0.028
Race    < 0.001    < 0.001
 Black 1.000 1.000   1.000 1.000 < 0.001
 White 0.490 0.447–0.536 < 0.001 0.490 0.447–0.536 < 0.001
 Hispanic/Latino 0.581 0.508–0.664 < 0.001 0.604 0.528–0.690 < 0.001
 Asian or Pacific Islander and others 0.799 0.710–0.899 < 0.001 0.798 0.710–0.898 < 0.001
SEER staging    0.001    0.007
 Localized 1.000 1.000   1.000 1.000  
 Regional 0.947 0.882–1.017 0.159 0.943 0.878–1.013 0.109
 Distant 1.116 1.023–1.116 0.013 1.087 0.996–1.186 0.061
If surgery
 Yes vs. No 1.685 1.409–2.016 < 0.001 1.657 1.383–1.985 < 0.001
Pathology grade    < 0.001    < 0.001
 Well differentiated 1.000 1.000   1.000 1.000  
 Moderately differentiated 0.871 0.787–0.963 0.007 0.868 0.785–0.961 0.006
 Poorly differentiated 0.775 0.686–0.875 < 0.001 0.814 0.720–0.919 0.001
 Undifferentiated 0.487 0.329–0.719 < 0.001 0.524 0.354–0.775 0.001
  1. Abbreviations: SPCRC, secondary primary colorectal cancer; RCC, right-sided colon cancer; LCC, left-sided colon cancer