Second primary colorectal cancer after the initial primary colorectal cancer

BMC Cancer

Table 2 Factors Associated With Secondary Primary CRC (SPCRC) Risk Among Survivors of colorectal cancer

Cancer type	Univariate Cox Regression			Multivariate Cox Regression
Cancer type	HR	95% CI	P	HR	95% CI	P
History of IPCRC			< 0.001			< 0.001
RCC	1.000	1.000		1.000	1.000
LCC	1.362	1.264–1.468	< 0.001	1.369	1.269–1.477	< 0.001
Rectosigmoid colon	1.031	0.951–1.118	< 0.454	1.090	1.003–1.184	0.041
Age at diagnosis			< 0.001			< 0.001
< 40	1.000	1.000		1.000	1.000
40–49	1.026	0.800–1.315	0.839	1.018	0.794–1.305	0.890
50–59	1.027	0.816–1.293	0.820	0.954	0.799–1.268	0.954
60–69	1.352	1.082–1.691	0.008	1.342	1.073–1.679	0.010
70–79	1.516	1.215–1.892	< 0.001	1.541	1.234–1.925	< 0.001
> 80	1.257	1.003–1.576	0.047	1.339	1.066–1.680	0.012
Sex
Female vs. Male	0.928	0.870–0.989	0.021	0.930	0.871–0.992	0.028
Race			< 0.001			< 0.001
Black	1.000	1.000		1.000	1.000	< 0.001
White	0.490	0.447–0.536	< 0.001	0.490	0.447–0.536	< 0.001
Hispanic/Latino	0.581	0.508–0.664	< 0.001	0.604	0.528–0.690	< 0.001
Asian or Pacific Islander and others	0.799	0.710–0.899	< 0.001	0.798	0.710–0.898	< 0.001
SEER staging			0.001			0.007
Localized	1.000	1.000		1.000	1.000
Regional	0.947	0.882–1.017	0.159	0.943	0.878–1.013	0.109
Distant	1.116	1.023–1.116	0.013	1.087	0.996–1.186	0.061
If surgery
Yes vs. No	1.685	1.409–2.016	< 0.001	1.657	1.383–1.985	< 0.001
Pathology grade			< 0.001			< 0.001
Well differentiated	1.000	1.000		1.000	1.000
Moderately differentiated	0.871	0.787–0.963	0.007	0.868	0.785–0.961	0.006
Poorly differentiated	0.775	0.686–0.875	< 0.001	0.814	0.720–0.919	0.001
Undifferentiated	0.487	0.329–0.719	< 0.001	0.524	0.354–0.775	0.001

Abbreviations: SPCRC, secondary primary colorectal cancer; RCC, right-sided colon cancer; LCC, left-sided colon cancer

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