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Table 4 PRKAA1 Polymorphisms with Gastric Cancer Risk by Tumor Classification

From: Genetic variations in PRKAA1 predict the risk and progression of gastric Cancer

Genotype Co Site DIF TNM
GCA NGCA Low Med-high T1-T2 T3-T4
Ca OR (95% CI)a P Ca OR (95% CI)a P Ca OR (95% CI)a P Ca OR (95% CI)a P Ca OR (95% CI)a P Ca OR (95% CI)a P
rs10074991
 AA 128 43 Reference   61 Reference   47 Reference   57 Reference   35 Reference   69 Reference  
 AG 261 73 0.80(0.51,1.24) 0.312 182 1.45(1.01,2.09) 0.043 104 1.09(0.73,1.63) 0.683 151 1.28(0.88,1.86) 0.203 88 1.23(0.79,1.94) 0.362 167 1.16(0.82,1.66) 0.409
 GG 101 24 0.66(0.37,1.16) 0.150 98 2.02(1.32,3.07) 0.001 44 1.17(0.71,1.93) 0.528 77 1.66(1.08,2.57) 0.022 36 1.33(0.77,2.29)) 0.308 86 1.51(0.99,2.28) 0.054
 AG/GG 362 97 0.77(0.50,1.16) 0.210 280 1.16(1.14,2.28) 0.007 148 1.20(0.76,1.65) 0.570 229 1.38(0.97,1.98) 0.074 124 1.27(0.82,1.95) 0.283 253 1.26(0.90,1.77) 0.171
 Additive model    0.82(2.62,1.08) 0.163   1.43(1.16,1.76) 0.001   1.09(0.86,1.40) 0.475   1.31(1.05,1.62) 0.016   1.17(0.89,1.53) 0.255   1.24(1.01,1.53) 0.039
rs13361707
 TT 129 43 Reference   60 Reference   47 Reference   56 Reference   35 Reference   68 Reference  
 TC 260 73 0.80(0.52,1.25) 0.330 183 1.51(1.05,2.17) 0.027 104 1.10(0.73,1.65) 0.641 152 1.32(0.91,1.93) 0.141 88 1.25(0.80,1.97) 0.331 168 1.20(0.84,1.71) 0.320
 CC 101 24 0.66(0.37,1.17) 0.157 98 2.08(1.36,3.16) 0.001 44 1.19(0.72,1.95) 0.495 78 1.71(1.11,2.65) 0.015 36 1.34(0.78,2.31) 0.290 86 1.55(1.02,2.34) 0.040
 TC/CC 361 97 0.77(0.51,1.17) 0.225 281 1.67(1.18,2.36) 0.004 148 1.13(0.77,1.67) 0.529 230 1.42(1.00,2.05) 0.050 124 1.28(0.83,1.98) 0.257 254 1.30(0.93,1.82) 0.125
 Additive model    0.82(0.62,1.09) 0.171   1.45(1.18,1.78) 0.001   1.10(0.86,1.40) 0.451   1.32(1.07,1.64) 0.012   1.18(0.90,1.54) 0.240   1.26(1.02,1.55) 0.030
rs154268
 TT 297 88 Reference   183 Reference   115 Reference   156 Reference   90 Reference   181 Reference  
 TC 176 48 0.89(0.59,1.33) 0.567 131 1.24(0.92,1.66) 0.153 70 1.05(0.74,1.49) 0.794 109 1.18(0.86,1.61) 0.299 63 1.12(0.85,1.82) 0.258 116 1.46(0.85,1.82) 0.704
 CC 17 4 0.77(0.25.2.39) 0.657 27 2.54(1.34,4.81) 0.004 10 1.46(0.65,3.31) 0.364 21 2.38(1.20,4.58) 0.010 6 1.14(0.43,3.02) 0.790 25 2.46(1.28,4.70) 0.007
 TC/CC 193 52 0.88(0.60,1.31) 0.535 158 1.36(1.03,1.81) 0.032 80 1.09(0.78,1.53) 0.614 130 1.28(0.95,1.73) 0.099 69 1.24(0.86,1.79) 0.253 141 1.19(0.89,1.58) 0.240
 Additive model    0.89(0.63,1.26) 0.508   1.40(1.10,1.76) 0.005   1.12(0.84,1.49) 0.449   1.33(1.04,1.70) 0.025   1.19(0.87,1.63) 0.289   1.27(1.00,1.61) 0.046
rs461404
 AA 298 88 Reference   182 Reference   114 Reference   156 Reference   90 Reference   180 Reference  
 GA 175 48 0.90(0.60,1.34) 0.596 131 1.25(0.93,1.68) 0.132 71 1.08(0.76,1.54) 0.668 108 1.18(0.86,1.61) 0.383 63 1.25(0.86,1.83) 0.243 116 1.08(0.80,1.46) 0.628
 GG 17 4 0.78(0.25,2.40) 0.659 28 2.67(1.42,5.04) 0.002 10 1.48(0.65,3.34) 0.349 22 2.47(1.27,4.79) 0.007 6 1.23(0.58,2.61) 0.787 26 2.59(1.36,4.93) 0.004
 GA/GG 192 52 0.89(0.60,1.32) 0.563 159 1.38(1.05,1.84) 0.023 81 1.12(0.80,1.58) 0.509 130 1.29(0.96,1.74) 0.116 69 1.25(0.86,1.80) 0.240 142 1.21(0.91,1.62) 0.187
 Additive model    0.90(0.63,1.27) 0.532   1.42(1.13,1.79) 0.003   1.14(0.85,1.52) 0.373   1.34(1.05,1.72) 0.019   1.19(0.87,1.64) 0.276   1.30(1.03,1.65) 0.029
  1. aAdjusted for age, gender, smoking, drinking, and Helicobacter pylori infection; GCA gastric cardia adenocarcinoma, NGCA non-gastric cardia adenocarcinoma, Ca, case Co control