Decreased methylation in the SNAI2 and ADAM23 genes associated with de-differentiation and haematogenous dissemination in breast cancers

Table 6 The risk estimation of analysed variables and clinical status for exclusively haematogenous versus lymphogenous dissemination in breast cancer patients (logistic regression adjusted for age)

	Variables	P value	OR	95% CI
CTC + LNM- vs. CTC-LNM+	↑ Methylation of ADAM23 in PT	0.023	0.45	0.229–0.898
	↑ Methylation of CXCL12 in PBCs	0.046	0.07	0.005–0.949
	↑ Methylation of TWIST1 in PBCs	0.050	0.03	0.001–0.998
	Tumour size > 20 mm	0.055	0.04	0.001–1.073

−2 Log likelihood = 15.22; R²(Cox and Snell) = 0.57; R²(Nagelkerke) = 0.81
Abbreviations: LNM lymph node metastases, CTC circulating tumour cells, OR odds ratio, CI confidence interval, ↑ continuous variable. Age and DNA methylation of genes significant in univariate analysis, hormone receptor and HER2 status, histological type, tumour size and Ki-67 proliferative index were analysed as independent variables, significant or borderline significant results are shown in the table

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