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Table 5 DNA methylation levels in primary tumours of CTC-negative and epithelial CTC and mesenchymal CTC-positive BC patients

From: Decreased methylation in the SNAI2 and ADAM23 genes associated with de-differentiation and haematogenous dissemination in breast cancers

  DNA methylation levels in primary tumour
Mean ± std. deviation (in %)
 
Genes CTC- epi CTC+ mes CTC+ P value*
ADAM23 14.17 ± 12.24a,b 4.56 ± 2.40a 4.92 ± 1.62b 0.001
uPA 13.29 ± 16.37 9.56 ± 8.75 19.33 ± 21.90 0.592
CXCL12 14.45 ± 14.09 7.10 ± 3.00 16.40 ± 15.51 0.287
TWIST1 24.08 ± 18.20 10.00 ± 8.55 24.86 ± 16.34 0.065
SNAI1 5.82 ± 7.14 2.89 ± 1.05c 8.40 ± 7.80c 0.004
SNAI2 7.11 ± 4.95d 3.70 ± 1.34d 6.85 ± 4.90 0.022
  1. *Kruskal-Wallis Test; Adjusted pairwise comparisons: aP = 0.003; bP = 0.015; cP = 0.004; dP = 0.018; A statistical two-tailed significance was regarded as P value < 0.05. Abbreviations: BC breast cancer, CTC circulating tumour cell, epi CTC epithelial circulating tumour cells, mes CTC mesenchymal circulating tumour cells