Fig. 3

ADAM23 methylation levels in PT and LMN samples of patients without and with mesenchymal circulating tumour cells. The length of the boxes is the interquartile range (IQR) that represents values between the 75th and 25th percentiles. The circle (○) labelled outliers (values more than 1.5 IQRs but less than 3 IQRs from the end of the box). Values more than three IQRs, extremes, are depicted by asterisk (*).The horizontal line represents median. Significance level is regarded as P < 0.05. Abbreviations: PT, primary tumour; LNM, lymph node metastases; mes CTC, mesenchymal circulating tumour cells