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Table 2 Tumor characteristics of the eligible studies

From: Tumor necrosis as a prognostic variable for the clinical outcome in patients with renal cell carcinoma: a systematic review and meta-analysis

Study Staging system Grading system TN+/TN- Stage 1–2/ 3–4 Grade 1–2/ 3–4 ccRCC/no-ccRCC Tumor size (cm)
Xia et al.2017 [12] 2010 AJCC Furman 41/252 212/81 248/45 293/0 NA
Wu et al.2017 [13] 2010 AJCC Furman 77/224 265/36 225/76 301/0 NA
Niu et al.2017 [14] 2010 AJCC Furman 75/309 295/89 255/129 384/0 Mean ± SD
4.1 ± 2.1
Kim et al.2017 [15] 2009 AJCC Furman 46/131 60/82 44/105 159/3 Median (range)
8 (1–117)
Gu et al.2017 [16] 2010 AJCC Furman 90/94 NA 70/94 161/23 NA
Gershman et al.2017 [17] 2010 AJCC WHO/ ISUP 111/27 31/106 6/132 105/33 Median (range)
10(8–13)
Chen et al.2017 [18] 2010 AJCC Furman 53/110 0/163 83/55 135/8 Mean ± SD
6.8 ± 3.5
Chang1 et al.2016 [19] 2010 AJCC Furman 182/51 169/64 135/96 233/0 NA
Volpe et al.2016 [3] 2002 AJCC Furman 60/130 190/0 155/35 156/34 Median (IQR)
4.9(3.5–7)
Khor et al.2016 [20] 2010 AJCC Furman 665/177 630/212 265/577 842/0 Median (range)
4.2(0.6–20)
NguyenHoang et al.2016 [21] 2010 AJCC Furman 78/294 292/100 259/133 392/0 Mean ± SD
4.3 ± 2.6
Errarte et al.2016 [22] 2010 AJCC Furman 30/29 32/27 24/35 59/0 Median (range)
7.9(2–19)
Byun et al.2016 [23] 2002 AJCC Furman 208/1076 1105/179 664/620 1114/170 Mean ± SD
4.08 ± 2.68
Huang et al.2015 [24] 2010 AJCC Furman 34/184 160/58 155/63 0/218 Median (IQR)
3.5(2.5–6)
Cornejo et al.2015 [25] NA Fuhrman/ ISUP 40/114 121/33 103/51 0/154 Mean (range)
5.1(0.4–17)
Teng et al.2014 [26] 2009 AJCC Furman 38/340 346/32 200/178 378/0 Mean ± SD
4.6 ± 2.6
Park et al.2014 [27] NA Furman 37/46 NA 13/70 83/0 NA
Oliveira et al.2014 [28] 2010 AJCC Furman 18/76 77/17 65/29 94/0 Mean ± SD
4.7 ± 2.6
Can et al.2014 [29] 2010 AJCC Furman 42/85 84/43 72/55 127/0 NA
Pichler et al.2013 [30] 2010 AJCC Furman 277/717 723/271 839 804/190 NA
Kruck et al.2013 [31] 2010 AJCC Furman 114/164 169/109 234/44 278/0 Mean ± SD
5.26 ± 2.91
Fukatsu et al.2013 [32] 2010 AJCC Furman 57/104 508/53 341/220 561/0 NA
Sukov et al.2013 [33] 2010 AJCC Furman 186/209 346/49 247/148 0/395 NA
Chang2 et al.2011 [34] 2002 AJCC Furman 139/189 240/88 216/112 232/96 NA
Leibovich et al.2010 [35] 2002 AJCC Furman 792/2090 1992/1070 1649/1413 1781/1281 NA
Katz et al.2010 [36] 2002 AJCC Furman 253/586 575/194 589/252 641/198 NA
Roos et al.2009 [37] 2002 AJCC Furman 10/108 0/118 63/55 109/16 Median (range)
8(2.5–20)
Coons et al.2009 [38] 2002 AJCC Furman 57/71 0/128 40/103 105/23 Median (range)
9.9 (3.5–21)
Pflanz et al.2008 [39] 2002WHO Thoenes 155/452 515/92 532/75 479/128 NA
Lee et al.2006 [40] 1997 AJCC Furman 131/354 382/103 364/221 419/66 NA
Lam et al.2005 [41] 1997 AJCC Fuhrman 168/143 157/153 186/119 270/41 NA
Tornberg et al.2016 [42] 2009 AJCC Furman 84/58 0/132 38/104 129/13 Mean ± SD
10.3 ± 3.6
Schiavina et al.2015 [43] 2009 AJCC Furman 49/136 0/185 46/139 150/35 Mean ± SD
8.05 ± 2.8
Ramsey et al.2008 [44] 1997 AJCC Furman 55/28 48/35 37/40 33/50 NA
  1. total numbers rows:36; TN+/TN tumor necrosis positive/ tumor necrosis negative, SD standard deviation, NA data not applicable, ccRCC/no-ccRCC clear cell renal cell carcinoma/non- clear cell renal cell carcinoma