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Table 1 Main characteristics of the eligible studies

From: Tumor necrosis as a prognostic variable for the clinical outcome in patients with renal cell carcinoma: a systematic review and meta-analysis

Study

Country

Recruitment period

No. of patients

Age (years)

Gender (m/f)

Follow-up (months)

Study design

Survival analysis

Surgery

Xia et al.2017 [12]

China

2005–2007

293

Median (range)

55 (15–86)

90/203

Median (range)

99.1 (2.63–120.47)

Retrospective

OS,PFS

nephrectomy

Wu et al.2017 [13]

China

2004–2012

301

Median (range)

53 (4–83)

206/95

Median (range)

51.6 (3–121)

Retrospective

OS

nephrectomy

Niu et al.2017 [14]

China

2008–2009

384

Mean ± SD

53.9 ± 14.9

273/111

Median (range)

73 (42–74)

Retrospective

OS,RFS

RN and PN

Kim et al.2017 [15]

Korea

2006–2012

177

Mean ± SD

62 ± 10.9

136/41

Median (range)

19.2 (0.2–63.8)

Retrospective

OS,PFS

nephrectomy

Gu et al.2017 [16]

China

2006–2014

184

Mean ± SD

54.3 ± 13

142/42

Mean ± SD

23.3 ± 14.6

Retrospective

OS, PFS

nephrectomy

Gershman et al.2017 [17]

USA

1980–2010

138

Mean (range)

63 (54–72)

91/47

Median (IQR)

102(67.2–130.8)

Retrospective

CSS, OS

RN and PN

Chen et al.2017 [18]

China

2006–2015

172

Mean ± SD

56.5 ± 12.4

123/40

Mean ± SD

34.4 ± 22.9

Retrospective

CSS,RFS

RN

Chang1 et al.2016 [19]

China

2008–2014

233

Median (IQR)

56(48–62)

170/63

Median (IQR)

68(41–71)

Retrospective

RFS

nephrectomy

Volpe et al.2016 [3]

Italy

2000–2010

308

Median (IQR)

65(57–73)

110/80

Median (IQR)

72(39–108)

Retrospective

CSS

RN

Khor et al.2016 [20]

USA

1985–2003

842

Median(range)

61.5(22.4–89)

527/315

Median (range)

73.2 (0.12–273.6)

Retrospective

OS

RN and PN

NguyenHoang et al.2016 [21]

China

2008–2009

392

Mean ± SD

55.2 ± 12.1

116/276

Median (range)

73 (39–74)

Retrospective

OS, RFS

RN and PN

Errarte et al.2016 [22]

Spain

NA

59

Mean (range)

59 (25–83)

45/14

Mean (range)

65 (1–240)

Retrospective

OS

nephrectomy

Byun et al.2016 [23]

Korea

2000–2014

1284

Mean ± SD

55.9 ± 12.9

913/371

Median (IQR)

39(19–69)

Retrospective

CSS

RN and PN

Huang et al.2015 [24]

China

1991–2011

218

Mean ± SD

58.9 ± 12.2

169/49

Median (IQR)

43(17.8–67.5)

Retrospective

RFS

RN and PN

Cornejo et al.2015 [25]

USA

1984–2010

154

Mean (range)

62.7 (26–86)

125/29

Mean (range)

73.9 (0.13–222)

Retrospective

CSS, OS

RN and PN

Teng et al.2014 [26]

China

2004–2009

378

Mean ± SD

53.4 ± 12.4

272/106

Median (range)

60 (2–97)

Retrospective

CSS, RFS

RN and PN

Park et al.2014 [27]

Korea

2006–2011

83

Mean ± SD

56.3 ± 10.5

60/23

Median (range)

18 (1–62)

Retrospective

OS, PFS

RN and PN

Oliveira et al.2014 [28]

Brazil

1988–2006

94

Mean ± SD

59.7 ± 12.3

67/27

Median

11.7

Retrospective

CSS

RN and PN

Can et al.2014 [29]

Turkey

1995–2012

127

Mean (range)

56 (26–80)

70/57

Mean (range)

46 (3–169)

Retrospective

CSS

RN and PN

Pichler et al.2013 [30]

Austria

2000–2010

994

Mean ± SD

63.2 ± 11.9

599/395

Mean (range)

48.1 (0–132)

Retrospective

CSS, OS

RN and PN

Kruck et al.2013 [31]

Germany

1993–2006

278

Mean ± SD

62.2 ± 12.5

194/84

Median (IQR)

65(20–100)

Retrospective

CSS, OS

RN and PN

Fukatsu et al.2013 [32]

Japan

1986–2008

561

Median(range)

60(21–89)

442/119

Median (range)

55.7 (1–246)

Retrospective

CSS

nephrectomy

Sukov et al.2013 [33]

USA

1970–2002

395

Median(range)

65(25–89)

327/68

NA

Retrospective

CSS

RN and PN

Chang2 et al.2011 [34]

China

2001–2006

328

Mean (range)

59.2 (23–89)

216/112

Mean (range)

46.5 (1.0–97.2)

Retrospective

OS

RN and PN

Leibovich et al.2010 [35]

USA

1970–2003

3062

NA

2,0160/1002

Median (range)

97.2 (0–432)

Retrospective

CSS

RN and PN

Katz et al.2010 [36]

USA

1989–2004

586

Median

61

530/311

Median (range)

61 (1–209)

Retrospective

CSS, OS

RN and PN

Roos et al.2009 [37]

Germany

1990–2006

118

Mean (range)

64.5 (37.8–84.9)

76/42

Median (range)

3.2 (0.3–16.1)

Retrospective

CSS, PFS

nephrectomy

Coons et al.2009 [38]

USA

1988–2006

128

Median(range)

64(35–87)

95/33

Median (range)

25.2 (0–124)

Retrospective

CSS, OS, RFS

nephrectomy

Pflanz et al.2008 [39]

Germany

1992–2006

607

Mean (range)

61.6 (18–84)

387/220

Median

54

Retrospective

CSS, OS

RN and PN

Lee et al.2006 [40]

Korea

1993–2003

485

Median(range)

55(26–81)

360/125

Median(range)

50.9(1–148.6)

Retrospective

CSS

RN and PN

Lam et al.2005 [41]

USA

1989–2000

311

Median(range)

62(27–89)

208/103

Median (range)

45 (0.3–117)

Retrospective

CSS

nephrectomy

Tornberg et al.2016 [42]

Finland

2006–2014

142

Median(range)

65(41–89)

95/47

Median (range)

31 (0–111)

Prospective

CSS

RN and cytoreductive

Schiavina et al.2015 [43]

Italy

2000–2013

185

Mean ± SD

63.3 ± 11.8

149/36

Median (IQR)

32(18–62)

Prospective

CSS

RN and PN

Ramsey et al.2008 [44]

UK

2001–2005

83

NA

50/33

Median

38

Prospective

CSS, RFS

nephrectomy

  1. total numbers rows:36; SD standard deviation, NA data not applicable, CSS cancer-specific survival, OS overall survival, RFS recurrence-free survival, PFS progression-free survival, RD radical nephrectomy, PN partial nephrectomy