Table 2 baseline characteristics of the subjects included in the study
From: Diagnostic role of circulating extracellular matrix-related proteins in non-small cell lung cancer
Variables | COL11A1 COL10A1 | COL11A1 COL10A1 | SPARC | SPARC |
|---|---|---|---|---|
Healthy Controls (n = 57) | Patients (n = 57) | Healthy Controls (n = 90) | Patients (n = 90) | |
Sex (%) | ||||
 Male | 20 (35%) | 20 (35%) | 62 (69%) | 62 (69%) |
 Female | 37 (65%) | 37 (65%) | 28 (31%) | 28 (31%) |
Age (mean,range) | 66 (55–74) | 65 (42–77) | 66 (55–74) | 66 (41–82) |
Packyears (mean,range) |  |  | 48 (20–112) | 48 (4–158) |
COPD (%) | ||||
 Present | 22 (39%) | 16 (28%) | 48 (53%) | 38 (42%) |
 Absent | 35 (61%) | 39 (68%) | 42 (47%) | 50 (56%) |
 NA |  | 2 (4%) |  | 2 (2%) |
COPD severity (%) | ||||
 Severe | 0 (0%) | 0 (0%) | 0 (0%) | 2 (2%) |
 Moderate | 5 (9%) | 2 (3%) | 4 (4%) | 13 (14%) |
 Mild | 17(30%) | 14 (25%) | 44 (49%) | 23 (26%) |
 No | 35 (61%) | 39 (68%) | 42 (47%) | 50 (56%) |
 NA |  | 2 (4%) |  | 2 (2%) |
Smoking history (%) | ||||
 Current | 40 (70%) | 21 (37%) | 66 (73%) | 64 (71%) |
 Former | 17 (30%) | 24 (42%) | 24 (27%) | 26 (29%) |
 Never | 0 (0%) | 12 (21%) |  |  |
Histology (%) | ||||
 Adenocarcinoma |  | 47 (82%) |  | 54 (60%) |
 Squamous |  | 10 (18%) |  | 22 (25%) |
 Others |  |  |  | 12 (13%) |
 NA |  |  |  | 2 (2%) |
Tumor stage (%) | ||||
 IA |  | 18 (31%) |  | 20 (22%) |
 IB |  | 3 (5%) |  | 12 (13%) |
 IIA |  | 9 (16%) |  | 9 (10%) |
 IIB |  | 4 (7%) |  | 3 (3%) |
 IIIA |  | 17 (30%) |  | 28 (31%) |
 IIIB |  | 1 (2%) |  | 5 (6%) |
 IV |  | 5 (9%) |  | 6 (7%) |
 NA |  |  |  | 7 (8%) |
CT treatment (%) | ||||
 Yes |  | 9 (16%) |  | 13 (14%) |
 No |  | 48 (84%) |  | 77 (86%) |
COL11A1 (median, IQR) | 0.837 (0.653–1.043) | 0.923 (0.759–1.172) |  |  |
COL10A1 (median, IQR) | 0.556 (0.471–0.647) | 0.739 (0.640–0.882) |  |  |
SPARC (median, IQR) |  |  | 0.437 (0.343–0.555) | 0.676 (0.501–0.956) |