Angiogenesis and radiological tumor growth in patients with glioblastoma

BMC Cancer

Table 1 Associations between MVDs and histopathological features

Histopathological features^a	vWF-MVD (Median, 95% CI, ρ)	CD105-MVD (Median, 95% CI, ρ)
Thromboses	p = 0.160	p = 0.125
- Not present	12.0 (8.0, 21.8)	9.3 (7.2, 17.2)
- Present	15.7 (15.5, 20.2)	13.3 (13.9, 18.4)
High cellular density	p = 0.345	p = 0.082
- Not present	14.7 (14.0, 19.3)	12.0 (12.1, 16.8)
- Present	17.3 (14.6, 23.2)	16.3 (13.9, 21.9)
Mitotic count^b	p = 0.004*	p = 0.001*
Mitotic count^b	ρ = 0.29	ρ = 0.33
High vascular density	p = 0.016*	p = 0.004*
- Not present	13.5 (12.9, 18.5)	11.3 (11.3, 15.8)
- Present	17.5 (16.5, 24.0)	16.5 (15.2, 22.9)

vWF-MVD Microvessel density count of von Willebrand factor. CD105-MVD Microvessel density count of CD105. CI Confidence interval. p: p-value. ρ Spearman correlation coefficient. ^a Subjectively assessed on hematoxylin-eosin sections. ^b Counted in hotspots for 10 high-power fields. *Statistically significant associations, p < 0.05

ISSN: 1471-2407