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Table 2 Comparison of clinical and tumor characteristic between patients who underwent surgery and who did not

From: Could local surgery improve survival in de novo stage IV breast cancer?

Variable Nonsurgical(N = 125) Surgical(N = 188) p value&
Age
  ≤ 50 83(43.7%) 1107(56.3%) 0.092
  > 50 42(34.1%) 781(65.9%)  
Menopause status
 Menses 72(36.8%) 1122(63.2%) 0.144
 Menopause 51(45.2%) 663(54.8%)  
Tumor size
  ≤ 5 cm 63(36.2%) 1111(63.8%) 0.018
  > 5 cm 60(50.0%) 560(50.0%)  
Lymph node involvement
 N0 5(17.9%) 223(82.1%) 0.018#
 N1 21(47.7%) 23(52.3%)  
 N2 31(43.7%) 340(56.3%)  
 N3 65(50.4%) 664(49.6%)  
HER-2 receptor status
 Amplified 49(37.1%) 783(62.9%) 0.657£
 No-amplified 67(41.6%) 994(58.4%)  
 Not known or equivocal(2+) 49(45.0%) 511(55.0)  
Hormone receptor status
 H+ 81 (38.2%) 1131 (61.8%) 0.588
 H- 39(41.5%) 555(58.5%)  
Molecular subtype
 Luminal A 19(34.5%) 36(65.5%) 0.194
 Luminal B 54(38.3%) 887(61.7%)  
 HER2 23(41.1%) 333 (58.9%)  
 Triple negative 12 (36.4%) 21 (63.6%)  
 Unknown 117 (60.7%) 911 (39.3%)  
Viscera metastasis
 Yes 80 (47.9) 887 (52.1) 0.002
 No 45 (30.8%) 9101 (69.2%)  
Bone metastasis
 Yes 75(43.9%) 996(56.1%) 0.120
 No 50(35.2%) 892(64.8%)  
CNS metastasis*
 Yes 6(54.5%) 5(45.5%) 0.314
 No 119(39.4%) 1183(60.6%)  
Soft tissue metastasis
 Yes 58(42.3%) 779(57.7%) 0.297
 No 67(38.1%) 1109(61.9%)  
No. of metastatic sites
  ≤ 3 107(37.2%) 1181(62.8%) < 0.001
  > 3 18(72%) 67(28%)  
Endocrine therapy$
 Yes 35(28.5%) 888(71.5%) 0.001
 No 90(47.4%) 9100(52.6%)  
Anti-HER2 therapy$
 Yes 24(33.8%) 447(66.2%) 0.055£
 No 98(41.0%) 1141(59.0%)  
 Unknown 3(100%) 0  
OFS*
 Yes 12(20.7%) 446(79.3%) 0.001
 No 113(44.3%) 1142(55.7%)  
Radiotherapy
 Yes 18(18.2%) 781(81.8%) < 0.001
 No 81(44.0%) 1103(56.0%)  
 Unknown 26(86.7%) 4(13.3%)  
  1. Abbreviation: * OFS = ovarian function suppression; CNS = central nervous system; $Endocrine therapy were subsequent to chemotherapy; anti-HER2 therapy were incorporated into or subsequent to chemotherapy; &×2 test, except £Fisher’ exact test
  2. P values in bold italic are considered statistically significant