Table 2 Comparison of clinical and tumor characteristic between patients who underwent surgery and who did not
From: Could local surgery improve survival in de novo stage IV breast cancer?
Variable | Nonsurgical(N = 125) | Surgical(N = 188) | p value& |
|---|---|---|---|
Age | |||
≤ 50 | 83(43.7%) | 1107(56.3%) | 0.092 |
> 50 | 42(34.1%) | 781(65.9%) | |
Menopause status | |||
Menses | 72(36.8%) | 1122(63.2%) | 0.144 |
Menopause | 51(45.2%) | 663(54.8%) | |
Tumor size | |||
≤ 5 cm | 63(36.2%) | 1111(63.8%) | 0.018 |
> 5 cm | 60(50.0%) | 560(50.0%) | |
Lymph node involvement | |||
N0 | 5(17.9%) | 223(82.1%) | 0.018# |
N1 | 21(47.7%) | 23(52.3%) | |
N2 | 31(43.7%) | 340(56.3%) | |
N3 | 65(50.4%) | 664(49.6%) | |
HER-2 receptor status | |||
Amplified | 49(37.1%) | 783(62.9%) | 0.657£ |
No-amplified | 67(41.6%) | 994(58.4%) | |
Not known or equivocal(2+) | 49(45.0%) | 511(55.0) | |
Hormone receptor status | |||
H+ | 81 (38.2%) | 1131 (61.8%) | 0.588 |
H- | 39(41.5%) | 555(58.5%) | |
Molecular subtype | |||
Luminal A | 19(34.5%) | 36(65.5%) | 0.194 |
Luminal B | 54(38.3%) | 887(61.7%) | |
HER2 | 23(41.1%) | 333 (58.9%) | |
Triple negative | 12 (36.4%) | 21 (63.6%) | |
Unknown | 117 (60.7%) | 911 (39.3%) | |
Viscera metastasis | |||
Yes | 80 (47.9) | 887 (52.1) | 0.002 |
No | 45 (30.8%) | 9101 (69.2%) | |
Bone metastasis | |||
Yes | 75(43.9%) | 996(56.1%) | 0.120 |
No | 50(35.2%) | 892(64.8%) | |
CNS metastasis* | |||
Yes | 6(54.5%) | 5(45.5%) | 0.314 |
No | 119(39.4%) | 1183(60.6%) | |
Soft tissue metastasis | |||
Yes | 58(42.3%) | 779(57.7%) | 0.297 |
No | 67(38.1%) | 1109(61.9%) | |
No. of metastatic sites | |||
≤ 3 | 107(37.2%) | 1181(62.8%) | < 0.001 |
> 3 | 18(72%) | 67(28%) | |
Endocrine therapy$ | |||
Yes | 35(28.5%) | 888(71.5%) | 0.001 |
No | 90(47.4%) | 9100(52.6%) | |
Anti-HER2 therapy$ | |||
Yes | 24(33.8%) | 447(66.2%) | 0.055£ |
No | 98(41.0%) | 1141(59.0%) | |
Unknown | 3(100%) | 0 | |
OFS* | |||
Yes | 12(20.7%) | 446(79.3%) | 0.001 |
No | 113(44.3%) | 1142(55.7%) | |
Radiotherapy | |||
Yes | 18(18.2%) | 781(81.8%) | < 0.001 |
No | 81(44.0%) | 1103(56.0%) | |
Unknown | 26(86.7%) | 4(13.3%) | |