Fig. 3From: Association between cyclooxygenase-2 (COX-2) 8473 T > C polymorphism and cancer risk: a meta-analysis and trial sequential analysisa. TSA for overall analysis under homozygote comparison. b. TSA for overall analysis under heterozygote comparison. The required information size was calculated based on a two side α = 5%, β = 20% (power 80%), and an anticipated relative risk reduction of 10%Back to article page