Table 4 Univariate and multivariate analysis for the overall survival and relapse-free survival according to the combined expression patterns of the nuclear expression of Ox-PTP and ɣH2AX

   −/−

34/169

1

<  0.001

1

<  0.001

   −/+

20/169

2.503 (0.762–8.224)

0.131

2.455 (0.747–8.067)

0.139

   +/−

38/169

5.471 (2.079–14.402)

<  0.001

5.876 (2.240–15.412)

<  0.001

   +/+

77/169

11.420 (4.545–28.697)

<  0.001

11.273 (4.489–28.311)

<  0.001

   −/−

34/169

1

<  0.001

1

<  0.001

   −/+ or +/−

58/169

4.405 (1.703–11.395)

0.002

4.609 (1.786–11.895)

0.002

   +/+

77/169

11.498 (4.572–28.917)

<  0.001

11.354 (4.517–28.543)

<  0.001

  I

1

0.003

1

0.003

  II

1.719 (0.617–4.790)

0.300

1.746 (0.627–4.865)

0.287

  III

2.417 (0.917–6.372)

0.074

2.647 (1.007–6.956)

0.048

  IV

4.725 (1.739–12.839)

0.002

4.858 (1.785–13.219)

0.002

  Venous invasion, presence (vs absence)

3.674 (2.056–6.564)

<  0.001

3.737 (2.098–6.658)

<  0.001

  −/−

1

<  0.001

1

<  0.001

   −/+

2.822 (0.523–15.882)

0.224

2.817 (0.511–15.527)

0.234

   +/−

13.147 (2.992–57.772)

<  0.001

14.430 (3.294–63.208)

<  0.001

   +/+

20.309 (4.801–85.912)

< 0.001

20.434 (4.831–86.435)

<  0.001

  I

1

0.002

1

0.002

   II

1.668 (0.597–4.663)

0.329

1.682 (0.602–4.701)

0.322

   III

2.909 (1.108–7.643)

0.030

3.171 (1.210–8.310)

0.019

   IV

5.009 (1.848–13.579)

0.002

5.058 (1.864–13.722)

0.001

   Venous invasion, presence (vs absence)

2.849 (1.649–4.920)

<  0.001

2.837 (1.646–4.890)

<  0.001

   −/−

1

< 0.001

1

< 0.001

   −/+ or +/−

7.882 (1.847–33.640)

0.005

8.297 (1.948–35.334)

0.004

  +/+

18.120 (4.311–76.156)

< 0.001

17.970 (4.279–75.470)

< 0.001