Table 5 Predicted target genes in representative set of enriched gene ontology biological process terms

G1/S transition of mitotic cell cycle

GO:0000082

CCNE2, ACVR1B, EIF4E, CACUL1, CAMK2G, CAMK2D, USP37, RANBP1, RPS6KB1, PPP3CA, PHF8, LATS2, RBBP8

19a: CACUL1, RBBP81

181a: RPS6KB1

regulation of establishment of cell polarity

GO:2000114

ROCK1, GATA3, KRIT1, RICTOR, ARFGEF1, KANK1

19a: ARFGEF1

181: KANK1

negative regulation of apoptotic process

GO:0043066

FKBP8, TAF9B, NAA15, FOXO1, TP63, CITED2, SETX, PTK2, CASP3, DAB2, PRKAA1, RARB, HSPA5, AGO4, DNAJC3, KLHL20, CDK1, PDCD10, ADAMTS20, ZNF830, CBL, ASIC2, IGF1, RHBDD1, UBE2B, ASCL1, HSP90B1, GSK3B, HIPK3, VEGFA, ARF4, MAPK8, MDM4, APBB2, CAMK1D

19a: HIPK3^a, MDM4, MAPK8, ADAMTS20, KLHL20

181a: HIPK3^a, HSP90B1, UBE2B,

TAF9B, DNAJC3

establishment of cell polarity

GO:0030010

RAB11FIP2, UST, RICTOR, WEE1, EPHB1, MARK1, KIF26B

19a: WEE1

181a: RAB11FIP2, MARK1

intrinsic apoptotic signaling pathway by p53 class mediator

GO:0072332

ZMAT1, ZMAT4, ZMAT3, PPP1R13B, ZNF385B, DDX5, ZNF346

19a: ZNF385B

negative regulation of extrinsic apoptotic signaling pathway

GO:2001237

PHIP, ZMYND11, NRP1, ITGA6, IGF1, PSME3, RPS6KB1, SGMS1, GCLM

19a: ZMYND11

181a: GCLM, RPS6KB1

histone ubiquitination

GO:0016574

SUZ12, UBE2A, HUWE1, UBE2B, PHC1

19a: UBE2A, SUZ12

181a: UBE2B

neuronal stem cell population maintenance

GO:0097150

NOTCH1, FOXO1, DLL1, FOXO3, CDH2, PROX1, MMP24

181a: PROX1

chromatin remodeling

GO:0006338

ATRX, TOP1, RSF1, HNF1A, GATA3, MORF4L2, INO80, CHD1, TP63, ARID1B, SMARCA2, RERE

19a: INO80^a, SMARCA2, ATRX

181a: INO80^a

positive regulation of cell-substrate adhesion

GO:0010811

PPM1F, SMOC2, CCDC80, JAK2, NID1, EDIL3, PRKCE, ABI3BP

19a: SMOC2

181a: ABI3BP

histone H3-K9 trimethylation

GO:0036124

BEND3, ARID4A, ARID4B

histone H2A ubiquitination

GO:0033522

UBE2A, UBR2, UBE2B

19a: UBE2A

181a: UBE2B

positive regulation of cell proliferation

GO:0008284

KMT2D, CNBP, CACUL1, ESM1, IL34, CNOT7, CNOT6, TGFB2, PTK2, S1PR1, KRAS, CNOT6L, RARB, LOC488215, INSR, ACER3, UBE2A, PDCD10, KLB, SLC25A5, MECP2, ROGDI, IGF1, DLL1, TET1, SUZ12, ADM, HIPK1, HDAC1, VEGFA, HBEGF, MAB21L1, CARM1, EIF5A2

18a: KLB

19a: S1PR1^a, CNOT7, CACUL1, NOT6, UBE2A, ROGDI, HIPK1, SUZ12

181a: S1PR1^a, ESM1, CARM1, ADM

negative regulation of cell migration

GO:0030336

PTPRJ, RAP2A, ADARB1, RAP2C, OSBPL8, ABHD2, KANK1, THY1, SFRP1, ROBO1, RRAS, TP53INP1, SRGAP2

19a: RAP2C

181a: KANK1, OSBPL8, ADARB1

histone H3-K4 trimethylation

GO:0080182

TET3, BEND3, ARID4A, KMT2A, CTR9

181a: KMT2A

stem cell population maintenance

GO:0019827

PHF19, EIF4E, NIPBL, MED28, MTF2, EOMES, KLF4, DDX6, CTR9

18a: PHF19

19a: DDX6

cell migration

GO:0016477

CCDC88A, AVL9, CDH2, VAV2, EPHB3, SDC4, TGFB2, SDC1, SORBS2, GSK3B, ARF4, CDC42BPA, JAK2, LIMD1, LAMC1, CSK, KCTD13, NFATC2, USP33

18a: SDC4, SORBS2

19a: USP33^a, NFATC2, CCDC88A, SDC1, EPHB3

181a: USP33^a, AVL9, CDC42BPA