Fig. 2
From: Impact of viral presence in tumor on gene expression in non-small cell lung cancer
Viral carcinogenesis pathway and differentially expressed genes in primary NSCLC tumors. The viral carcinogenesis was displayed in part, focusing on three over-expressed genes in virus-infected Primary NSCLC tumors in comparison with uninfected primary tumors. Eclipse and rectangle boxes indicate viral product and host cellular target, respectively. a HPN (hepsin), b ACTN4 (actinin alpha 4), and c GP130 (interleukin 6 signal transducer) are host cellular targets of three different viral oncoproteins (HBx, Tax, and vIL-6) that lead to cell proliferation/survival, regulation of actin cytoskeleton, and proliferation angiogenesis, respectively