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Table 3 Univariate analysis of clinicopathological characteristics associated with survival

From: Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma

Variables

Parameters

n

Overall survival (%)

Progression-free survival (%)

3-year

5-year

p a

HR (95% CI)

p b

3-year

5-year

p a

HR (95% CI)

p b

Age (year)

<  60

167

83.8

81.1

 

1

 

75.4

72.6

 

1

 

≥ 60

194

74.7

68.2

0.008*

1.80 (1.16–2.79)

0.009*

63.6

59.5

0.019*

1.56 (1.07–2.28)

0.020*

Gender

Female

8

75.0

35.7

 

1

 

62.5

–

 

1

 

Male

353

79.0

74.1

0.372

0.60 (0.19–1.89)

0.379

69.2

65.7

0.576

0.72 (0.23–2.28)

0.580

Tumor location

Glottic

280

83.9

79.5

 

1

 

74.1

70.2

 

1

 

Supraglottic

70

65.7

60.5

 

2.33 (1.46–3.70)

< 0.001*

57.3

54.9

 

1.77 (1.16–2.70)

0.008*

Subglottic

11

36.4

24.2

< 0.001*

5.53 (2.62–11.69)

< 0.001*

12.1

–

< 0.001*

4.50 (2.24–9.03)

< 0.001*

T classification

T1-T2

241

92.1

87.4

 

1

 

83.0

79.4

 

1

 

T3-T4

120

52.5

47.7

< 0.001*

5.15 (2.89–8.72)

< 0.001*

43.2

39.8

< 0.001*

4.09 (2.81–5.95)

< 0.001*

N classification

N0

320

84.1

79.1

 

1

 

74.1

70.1

 

1

 

N1-N2

41

39.0

35.8

< 0.001*

4.32 (2.73–6.84)

< 0.001*

31.7

31.7

< 0.001*

3.13 (2.05–4.79)

< 0.001*

TNM stage

I-II

232

94.0

89.0

 

1

 

84.6

80.9

 

1

 

III-IV

129

51.9

47.5

< 0.001*

6.56 (3.63–9.35)

< 0.001*

43.3

40.1

< 0.001*

4.46 (3.04–6.56)

< 0.001*

Histology

Well-moderate

294

85.4

80.5

 

1

 

75.23

71.5

 

1

 

Poor

67

50.7

46.4

< 0.001*

3.49 (2.28–5.34)

< 0.001*

43.1

40.9

< 0.001*

2.69 (1.83–3.95)

< 0.001*

Laryngectomy

Partial

287

87.8

82.2

 

1

 

77.6

72.7

 

1

 

Total

74

44.6

39.6

< 0.001*

5.06 (3.33–7.68)

< 0.001*

38.1

34.3

< 0.001*

3.22 (2.22–4.67)

< 0.001*

Adjuvant therapy

No

273

79.9

75.0

 

1

 

70.2

66.5

 

1

 

Yes

88

76.1

71.4

0.539

1.16 (0.72–1.87)

0.541

65.5

63.0

0.283

1.25 (0.83–1.89)

0.286

Medication

No

314

79.0

73.7

 

1

 

68.1

65.0

 

1

 

Yes

47

78.7

76.1

0.863

0.95 (0.50–1.78)

0.864

74.4

68.7

0.590

0.86 (0.49–1.50)

0.592

Comorbidities

No

274

78.1

72.8

 

1

 

68.0

65.6

 

1

 

Yes

87

81.6

78.5

0.340

0.77 (0.47–1.31)

0.342

72.6

63.7

0.764

0.94 (0.61–1.45)

0.765

  1. *Statistically significant p < 0.05
  2. athe p value for log-rank test b the p value for HR in Cox analysis
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