Variables | Parameters | n | Overall survival (%) | Progression-free survival (%) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
3-year | 5-year | p a | HR (95% CI) | p b | 3-year | 5-year | p a | HR (95% CI) | p b | |||
Age (year) | < 60 | 167 | 83.8 | 81.1 | 1 | 75.4 | 72.6 | 1 | ||||
≥ 60 | 194 | 74.7 | 68.2 | 0.008* | 1.80 (1.16–2.79) | 0.009* | 63.6 | 59.5 | 0.019* | 1.56 (1.07–2.28) | 0.020* | |
Gender | Female | 8 | 75.0 | 35.7 | 1 | 62.5 | – | 1 | ||||
Male | 353 | 79.0 | 74.1 | 0.372 | 0.60 (0.19–1.89) | 0.379 | 69.2 | 65.7 | 0.576 | 0.72 (0.23–2.28) | 0.580 | |
Tumor location | Glottic | 280 | 83.9 | 79.5 | 1 | 74.1 | 70.2 | 1 | ||||
Supraglottic | 70 | 65.7 | 60.5 | 2.33 (1.46–3.70) | < 0.001* | 57.3 | 54.9 | 1.77 (1.16–2.70) | 0.008* | |||
Subglottic | 11 | 36.4 | 24.2 | < 0.001* | 5.53 (2.62–11.69) | < 0.001* | 12.1 | – | < 0.001* | 4.50 (2.24–9.03) | < 0.001* | |
T classification | T1-T2 | 241 | 92.1 | 87.4 | 1 | 83.0 | 79.4 | 1 | ||||
T3-T4 | 120 | 52.5 | 47.7 | < 0.001* | 5.15 (2.89–8.72) | < 0.001* | 43.2 | 39.8 | < 0.001* | 4.09 (2.81–5.95) | < 0.001* | |
N classification | N0 | 320 | 84.1 | 79.1 | 1 | 74.1 | 70.1 | 1 | ||||
N1-N2 | 41 | 39.0 | 35.8 | < 0.001* | 4.32 (2.73–6.84) | < 0.001* | 31.7 | 31.7 | < 0.001* | 3.13 (2.05–4.79) | < 0.001* | |
TNM stage | I-II | 232 | 94.0 | 89.0 | 1 | 84.6 | 80.9 | 1 | ||||
III-IV | 129 | 51.9 | 47.5 | < 0.001* | 6.56 (3.63–9.35) | < 0.001* | 43.3 | 40.1 | < 0.001* | 4.46 (3.04–6.56) | < 0.001* | |
Histology | Well-moderate | 294 | 85.4 | 80.5 | 1 | 75.23 | 71.5 | 1 | ||||
Poor | 67 | 50.7 | 46.4 | < 0.001* | 3.49 (2.28–5.34) | < 0.001* | 43.1 | 40.9 | < 0.001* | 2.69 (1.83–3.95) | < 0.001* | |
Laryngectomy | Partial | 287 | 87.8 | 82.2 | 1 | 77.6 | 72.7 | 1 | ||||
Total | 74 | 44.6 | 39.6 | < 0.001* | 5.06 (3.33–7.68) | < 0.001* | 38.1 | 34.3 | < 0.001* | 3.22 (2.22–4.67) | < 0.001* | |
Adjuvant therapy | No | 273 | 79.9 | 75.0 | 1 | 70.2 | 66.5 | 1 | ||||
Yes | 88 | 76.1 | 71.4 | 0.539 | 1.16 (0.72–1.87) | 0.541 | 65.5 | 63.0 | 0.283 | 1.25 (0.83–1.89) | 0.286 | |
Medication | No | 314 | 79.0 | 73.7 | 1 | 68.1 | 65.0 | 1 | ||||
Yes | 47 | 78.7 | 76.1 | 0.863 | 0.95 (0.50–1.78) | 0.864 | 74.4 | 68.7 | 0.590 | 0.86 (0.49–1.50) | 0.592 | |
Comorbidities | No | 274 | 78.1 | 72.8 | 1 | 68.0 | 65.6 | 1 | ||||
Yes | 87 | 81.6 | 78.5 | 0.340 | 0.77 (0.47–1.31) | 0.342 | 72.6 | 63.7 | 0.764 | 0.94 (0.61–1.45) | 0.765 |