Fig. 1

Whole-genome DNA methylation and gene expression analyses. a, Heatmap of differentially methylated genes. DNA extracted from S05, 182^R-6, and TAM^R-1 cells was treated with DNase-free RNase and bisulfite converted; DNA methylation assay, data collection, and analysis were performed as described in “Methods”. b, Heatmap of differentially expressed genes. Total RNA isolated from S05, 182^R-6, and TAM^R-1 cells was subjected to gene expression profiling; the detailed procedures for library preparation, hybridization, detection, BeadChip statistical analysis, and data processing have been described previously [19]. c and d, The number of differentially methylated genes (c) and differentially expressed genes (d) was presented with a Venn diagram