Inclusion criteria | Exclusion criteria for | ||
---|---|---|---|
BEST3 data collection | Cytosponge procedure | Upper GI endoscopy | |
• Male and female • Aged ≥50 • Records of ≥6 months of prescription for acid-suppressant medication in the last year | • Recorded regular prescriptions of NSAIDs • Recorded upper GI endoscopy in the previous 5 years as identified from the practice database • Recorded diagnosis of a current or previous oro-pharynx, oesophageal or gastro-oesophageal tumour • Recorded diagnosis of BE • Unable to attend the GP surgery • Deemed not fit enough by their GP, including lacking capacity | • Meeting the guidelines for an urgent endoscopy referral according to NICE guidelines • Recorded diagnosis of an oro-pharynx, oesophageal or gastro-oesophageal tumour (T2 staging and above), or symptoms of dysphagia • Difficulty in swallowing due to a known cerebrovascular accident or neurological disorder • Recorded oesophageal varices, cirrhosis of the liver • Inability to temporarily discontinue anti-thrombotic medication prior to procedure • Having eaten and drank within the preceding 4 h • Received prior surgical intervention to the oesophagus • Known pregnancy • Lacking capacity to provide informed consent | • Upper GI endoscopy during the study period • Severe hypertension (e.g. systolic > 200 diastolic > 100) • Myocardial infarction or any cardiac event within the previous 6 months • Cerebrovascular event or other neurological disorder where swallowing has been affected within the previous 6 months • Any previous treatment such as Photodynamic therapy (PDT) or Radio Frequency Ablation (RFA) to the oesophagus • Anticoagulation therapy/ medication on day of procedure (warfarin, heparin or tinzaparin) according to local guidelines • Other medical condition: low platelets or blood abnormalities that may cause excessive bleeding post procedure • Eaten or drank within the previous 6 h • Preference for sedation and has not brought anyone to accompany them at home. Follow local guidelines • Known pregnancy • Lacking capacity to provide informed consent |