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Table 1 Clinicopathological features of female cats with mammary carcinoma enrolled in this study (n = 115)

From: CXCR4 and its ligand CXCL12 display opposite expression profiles in feline mammary metastatic disease, with the exception of HER2-overexpressing tumors

Clinicopathological feature No. of animals (%) Clinicopathological feature No. of animals (%)
Age (Mean ± SD) 11.40 ± 2.82 years HP classification  
 <10 years 32 (27.8)  Papillary-cystic carcinoma 7 (6.1)
 ≥10 years 79 (68.7)  Cribriform carcinoma 10 (8.7)
 Unknown 4 (3.5)  Mucinous carcinoma 11 (9.5)
 Solid carcinoma 20 (17.4)
 Tubular carcinoma 30 (26.1)
 Tubulopapillary carcinoma 37 (32.2)
Breed   Malignancy grade  
 Not determined 95 (82.6)  I 3 (2.6)
 Siamese 10 (8.7)  II 21 (18.3)
 Persian 7 (6.1)  III 91 (79.1)
 Norwegian Forest Cat 3 (2.6)   
Spayed   Necrosis  
 No 59 (51.3)  No 30 (26.1)
 Yes 52 (45.2)  Yes 85 (73.9)
 Unknown 4 (3.5)   
Contraceptives   Lymphatic invasion  
 No 35 (30.4)  No 91 (79.1)
 Yes 53 (46.1)  Yes 24 (20.9)
 Unknown 27 (23.5)   
Treatment   Lymphocytic infiltration  
 Mastectomy 97 (84.3)  No 33 (28.7)
 Mastectomy + Chemo 8 (7.0)  Yes 80 (69.6)
 None 10 (8.7)  Unknown 2 (1.7)
Multiple mammary tumors   Tumor ulceration  
 No 42 (36.5)  No 96 (83.5)
 Yes 73 (63.5)  Yes 19 (16.5)
Disease stage (TNM)   Ki-67 index  
 I 25 (21.7)  Low (<14%) 31 (26.9)
 II 20 (17.4)  High (≥14%) 83 (72.2)
 III 52 (45.2)  Unknown 1 (0.9)
 IV 13 (11.3)   
 Not determined 5 (4.4)   
Lymph node status   PR status  
 Negative 61 (53.0)  Negative 66 (57.4)
 Positive 44 (38.3)  Positive 49 (42.6)
 Unknown 10 (8.7)   
Localization   ER status  
 M1 17 (14.8)  Negative 86 (74.8)
 M2 22 (19.1)  Positive 29 (25.2)
 M3 43 (37.4)   
 M4 26 (22.6)   
 Unknown 7 (6.1)   
Recurrence   HER2 status  
 No 39 (33.9)  Negative 83 (72.2)
 Yes 64 (55.7)  Positive 32 (27.8)
 Unknown 12 (10.4)   
Survival   Serum CXCL12 levels  
 No 53 (46.1)  Negative (<2 ng/ml) 17 (14.8)
 Yes 58 (50.4)  Positive (≥2 ng/ml) 25 (21.7)
 Unknown 4 (3.5)  Not determined 73 (63.5)
Tumor size
 ≤1 cm 21 (18.3)   
 >1 cm 94 (81.7)   
  1. HP Histopathological
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