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Fig. 2 | BMC Cancer

Fig. 2

From: CXCR4 and its ligand CXCL12 display opposite expression profiles in feline mammary metastatic disease, with the exception of HER2-overexpressing tumors

Fig. 2

CXCR4 and CXCL12 expression in primary tumors (PT) and metastases significantly contribute to serum CXCL12 concentration. CXCL12 levels were quantified in blood serum by ELISA while the expression of CXCR4 in PT (a) and metastases (b) and of CXCL12 in PT (c) and metastases (d), was assessed by immunohistochemistry. The non-parametric Mann-Whitney was used to compare serum CXCL12 levels between the cats having CXCR4/CXCL12-negative tumors and cats with CXCR4/CXCL12-positive tumors. Bars represent the mean value ± SEM and * indicates a significant difference

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