Clinical response and pharmacokinetics of bendamustine as a component of salvage R-B(O)AD therapy for the treatment of primary central nervous system lymphoma (PCNSL)

Table 2 Population PK model parameter estimates and nonparametric bootstrap 90% confidence intervals

Parameter	Estimate	RSE (%) /CV (%)	Bootstrap Replicates
Parameter	Estimate	RSE (%) /CV (%)	Median	CI (90%)
V₁	14.9	19.2	14.1	4.9	20.7
CL	32.5	10.5	31.4	23.9	39.2
V₂	0.508	14.4	0.455	0.186	0.846
Q₁	0.238	15.3	0.205	0.041	0.660
V₃	0.323	9.8	0.322	0.186	0.442
Q₂	0.569	15.8	0.569	0.344	0.836
V₄	0.032	40.9	0.032	0.014	0.041
Q₃	0.793	16.8	0.795	0.573	1.360
CL_csf	0.075	43.5	0.075	0.059	0.140
IIV V₁	0.230	42.9	0.220	0.011	0.480
IIV CL	0.089	39.9	0.086	0.014	0.190
RV	0.420	17.4	0.390	0.210	0.620

Abbreviations: RSE (%, for structural parameter estimates), relative standard error; CV (%, for IIV), coefficient of variance; CI, confidence interval; V (L), volume of distribution; CL (L/h), elimination clearance; Q (L/h), inter-compartmental clearance; CLcsf (L/h), CSF compartment clearance; IIV, inter-individual variability; RV, residual variability

ISSN: 1471-2407