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Table 2 Population PK model parameter estimates and nonparametric bootstrap 90% confidence intervals

From: Clinical response and pharmacokinetics of bendamustine as a component of salvage R-B(O)AD therapy for the treatment of primary central nervous system lymphoma (PCNSL)

Parameter Estimate RSE (%)
/CV (%)
Bootstrap Replicates
Median CI (90%)
V1 14.9 19.2 14.1 4.9 20.7
CL 32.5 10.5 31.4 23.9 39.2
V2 0.508 14.4 0.455 0.186 0.846
Q1 0.238 15.3 0.205 0.041 0.660
V3 0.323 9.8 0.322 0.186 0.442
Q2 0.569 15.8 0.569 0.344 0.836
V4 0.032 40.9 0.032 0.014 0.041
Q3 0.793 16.8 0.795 0.573 1.360
CLcsf 0.075 43.5 0.075 0.059 0.140
IIV V1 0.230 42.9 0.220 0.011 0.480
IIV CL 0.089 39.9 0.086 0.014 0.190
RV 0.420 17.4 0.390 0.210 0.620
  1. Abbreviations: RSE (%, for structural parameter estimates), relative standard error; CV (%, for IIV), coefficient of variance; CI, confidence interval; V (L), volume of distribution; CL (L/h), elimination clearance; Q (L/h), inter-compartmental clearance; CLcsf (L/h), CSF compartment clearance; IIV, inter-individual variability; RV, residual variability