Fig. 2
Relationship between interim response status and a) plasma Cmax and b) CSF Cmax bendamustine concentrations, and tumor location. Deep structures include periventricular regions, basal ganglia, brainstem, and cerebellum regions. Closed circles (•) represent responders and open circles (°) non-responders. Patient identification numbers are notated and the dashed line depicts mean Cmax values for plasma and CSF. Bendamustine exposure was not significantly higher for the patient resulting in treatement related death (ID No. 8)