Fig. 2

Odds ratios for cardiotoxicity associated with the CYP3A5 rs4646450 genotype among subgroups of patients and also in the whole cohort. Results of the univariate logistic regression analysis performed on subpopulations of patients and also on the total cohort of patients. Subpopulations are determined based on the following factors: diagnosis, age at diagnosis, gender, risk group, chemotherapy protocol, cumulative ANT dose, recidive occurred. Black boxes represent OR, the number of cases is proportional with the width of the boxes. The lengths of the horizontal lines depict the 95% confidence intervals. Analysis of OR was not accomplished if the number of cases was 0. Abbreviations: ALL, acute lymphoblastic leukemia; OSC, osteosarcoma; no, number; yr., year; SR, standard-risk; IR, intermediate-risk; HR, high-risk