Table 2 Response to anti PD-1 according to BRAF status
From: Ineffective anti PD-1 therapy after BRAF inhibitor failure in advanced melanoma
Wild-type BRAF | Mutated BRAF | p | |
|---|---|---|---|
n = 33 | n = 41 | ||
Objective Response Rate, n (%) | 15 (45.5) | 5 (12.2) | 0.003 |
Disease Control Rate, n (%) | 19 (57.6) | 10 (24.4) | 0.008 |
Progressive Disease, n (%) | 14 (42.4) | 31 (42.4) | |
Median Progression-Free Survival, months [95%CI] | 5 [0.2–9.8] | 2 [1.6–2.4] | < 0.001 |
Median Overall Survival, months [95%CI] | 20 [5.4–34.6] | 7 [4.0–10.0] | < 0.001 |