Table 1 DNA methylation alterations in promoter regions of TP53 signaling pathway genes in CRC and AD tissues compared to NAT samples

ATM

ATM serine/threonine kinase

11

108092901

108093000

0.22*

ATR

ATR serine/threonine kinase

3

142298701

142298800

0.26*

BAX

BCL2 associated X, apoptosis regulator

19

49457601

49457700

−0.20*

BBC3

BCL2 binding component 3

19

47734901

47735000

0.29*

47735001

47735100

0.24*

47735601

47735700

−0.17*

CASP8

caspase 8

2

202098501

202098600

0.31**

202098601

202098700

0.26*

202122001

202122100

0.21*

202122101

202122200

0.32*

202123101

202123200

0.27*

202123201

202123300

0.43***

CCND3

cyclin D3

6

41908401

41908500

−0.20*

42016801

42016900

0.21*

42016901

42017000

0.27*

CCNE1

cyclin E1

19

30303701

30303800

0.51**

CDK1

cyclin dependent kinase 1

10

62539101

62539200

−0.25*

62539201

62539300

−0.33**

CDK6

cyclin dependent kinase 6

7

92466601

92466700

0.33**

92466701

92466800

0.29*

92466801

92466900

0.26*

CDKN1A

cyclin dependent kinase inhibitor 1A

6

36644601

36644700

0.23*

CDKN2A

cyclin dependent kinase inhibitor 2A

9

21975301

21975400

0.29*

21993901

21994000

0.25*

21994001

21994100

0.37*

CHEK1

checkpoint kinase 1

11

125496401

125496500

0.23*

125496501

125496600

0.42**

125496601

125496700

0.32*

CYCS

cytochrome c, somatic

7

25164001

25164100

0.32*

25164201

25164300

0.33*

25165801

25165900

0.17*

DDB2

damage specific DNA binding protein 2

11

47237401

47237500

−0.28*

47237501

47237600

−0.29*

EI24

EI24, autophagy associated transmembrane protein

11

125438801

125438900

0.29*

125438901

125439000

0.46**

125439001

125439100

0.36*

FAS

Fas cell surface death receptor

10

90751601

90751700

−0.43***

90751701

90751800

−0.22*

90751801

90751900

−0.45***

−0.27*

90751901

90752000

−0.26*

GADD45A

growth arrest and DNA damage inducible alpha

1

68150801

68150900

0.30*

GTSE1

G2 and S-phase expressed 1

22

46693501

46693600

−0.26*

−0.31**

46693601

46693700

−0.33**

IGF1

insulin like growth factor 1

12

102871901

102872000

−0.26*

−0.23*

IGFBP3

insulin like growth factor binding protein 3

7

45961101

45961200

0.46*

45961401

45961500

0.54**

0.73***

45961501

45961600

0.48*

0.60***

45961701

45961800

0.42**

MDM4

MDM4, p53 regulator

1

204486501

204486600

0.14*

PTEN

phosphatase and tensin homolog

10

89621101

896212200

−0.34*

RCHY1

ring finger and CHY zinc finger domain containing 1

4

76439201

76439300

−0.23*

76440301

76440400

−0.29*

RFWD2

ring finger and WD repeat domain 2

1

176177801

176177900

−0.33*

RRM2

ribonucleotide reductase regulatory subunit M2

2

10261301

10261400

0.32*

SERPINE1

serpin family E member 1

7

100773001

100773100

0.24*

SESN1

sestrin 1

6

109331401

109331500

0.27*

109416501

109416600

0.11*

SESN2

sestrin 2

1

28585601

28585700

0.24*

SESN3

sestrin 3

11

94965001

94965100

−0.24*

SFN

stratifin

1

27189901

27190000

−0.35*

27190301

27190400

−0.34*

SHISA5

shisa family member 5

3

48513701

48513701

0.24*

THBS1

thrombospondin 1

15

39871901

39872000

−0.27*

39872801

39872900

−0.22*

TP73

tumor protein p73

1

3567901

3567901

0.58**

0.82***

3568001

3568001

0.53*

0.81***

3568101

3568101

0.26*

TSC2

TSC complex subunit 2

16

2097201

2097300

−0.26*