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Table 1 DNA methylation alterations in promoter regions of TP53 signaling pathway genes in CRC and AD tissues compared to NAT samples

From: Gene promoter and exon DNA methylation changes in colon cancer development – mRNA expression and tumor mutation alterations

Gene symbol Gene name chr start stop Δβ
(CRC-NAT)
Δβ
(AD-NAT)
ATM ATM serine/threonine kinase 11 108092901 108093000   0.22*
ATR ATR serine/threonine kinase 3 142298701 142298800 0.26*  
BAX BCL2 associated X, apoptosis regulator 19 49457601 49457700   −0.20*
BBC3 BCL2 binding component 3 19 47734901 47735000 0.29*
  47735001 47735100 0.24*
  47735601 47735700 −0.17*
CASP8 caspase 8 2 202098501 202098600   0.31**
  202098601 202098700 0.26*
  202122001 202122100 0.21*
  202122101 202122200 0.32*
  202123101 202123200 0.27*  
  202123201 202123300 0.43***
CCND3 cyclin D3 6 41908401 41908500   −0.20*
  42016801 42016900 0.21*
  42016901 42017000 0.27*
CCNE1 cyclin E1 19 30303701 30303800 0.51**  
CDK1 cyclin dependent kinase 1 10 62539101 62539200   −0.25*
  62539201 62539300 −0.33**
CDK6 cyclin dependent kinase 6 7 92466601 92466700 0.33**
  92466701 92466800 0.29*
  92466801 92466900 0.26*
CDKN1A cyclin dependent kinase inhibitor 1A 6 36644601 36644700 0.23*  
CDKN2A cyclin dependent kinase inhibitor 2A 9 21975301 21975400 0.29*
  21993901 21994000   0.25*
  21994001 21994100 0.37*
CHEK1 checkpoint kinase 1 11 125496401 125496500 0.23*
  125496501 125496600 0.42**
  125496601 125496700 0.32*
CYCS cytochrome c, somatic 7 25164001 25164100 0.32*
  25164201 25164300 0.33*
  25165801 25165900 0.17*  
DDB2 damage specific DNA binding protein 2 11 47237401 47237500   −0.28*
  47237501 47237600 −0.29*
EI24 EI24, autophagy associated transmembrane protein 11 125438801 125438900 0.29*  
  125438901 125439000 0.46**
  125439001 125439100 0.36*
FAS Fas cell surface death receptor 10 90751601 90751700 −0.43***
  90751701 90751800 −0.22*
  90751801 90751900 −0.45*** −0.27*
  90751901 90752000 −0.26*  
GADD45A growth arrest and DNA damage inducible alpha 1 68150801 68150900   0.30*
GTSE1 G2 and S-phase expressed 1 22 46693501 46693600 −0.26* −0.31**
  46693601 46693700   −0.33**
IGF1 insulin like growth factor 1 12 102871901 102872000 −0.26* −0.23*
IGFBP3 insulin like growth factor binding protein 3 7 45961101 45961200   0.46*
  45961401 45961500 0.54** 0.73***
  45961501 45961600 0.48* 0.60***
  45961701 45961800   0.42**
MDM4 MDM4, p53 regulator 1 204486501 204486600 0.14*
PTEN phosphatase and tensin homolog 10 89621101 896212200 −0.34*  
RCHY1 ring finger and CHY zinc finger domain containing 1 4 76439201 76439300   −0.23*
  76440301 76440400 −0.29*
RFWD2 ring finger and WD repeat domain 2 1 176177801 176177900 −0.33*  
RRM2 ribonucleotide reductase regulatory subunit M2 2 10261301 10261400 0.32*
SERPINE1 serpin family E member 1 7 100773001 100773100   0.24*
SESN1 sestrin 1 6 109331401 109331500 0.27*
  109416501 109416600 0.11*
SESN2 sestrin 2 1 28585601 28585700 0.24*  
SESN3 sestrin 3 11 94965001 94965100 −0.24*
SFN stratifin 1 27189901 27190000   −0.35*
  27190301 27190400 −0.34*
SHISA5 shisa family member 5 3 48513701 48513701 0.24*
THBS1 thrombospondin 1 15 39871901 39872000 −0.27*  
  39872801 39872900 −0.22*
TP73 tumor protein p73 1 3567901 3567901 0.58** 0.82***
  3568001 3568001 0.53* 0.81***
  3568101 3568101 0.26*
TSC2 TSC complex subunit 2 16 2097201 2097300 −0.26*
  1. p < 0.05 *; p < 0.01 **; p < 0.001 ***