Fig. 4

Box plots of DMRs in TP53 pathway gene promoters with the highest DNA methylation differences between CRC and NAT samples. Box plots represent the DNA methylation levels (β-values) of differentially methylated regions (DMRs) in TP53 pathway gene promoters showing the highest DNA methylation differences between CRC and NAT tissue samples. Individual DNA methylation level values are shown by red dots, and the median and standard deviation of the β-values are also demonstrated. The names of the DMRs indicate the official gene symbol_number of the chromosome_start position of the DMR. NAT = normal adjacent tissue, CRC = colorectal cancer, CASP8 = caspase 8, CCNE1 = cyclin E1, EI24 = EI24 autophagy associated transmembrane protein, FAS = Fas cell surface death receptor, IGFBP3 = insulin-like growth factor binding protein 3, TP73 = tumor protein p73