Table 1 Quantitative parameters between the responder and non-responder groups

ADC (mm²/s)

19.378

< 0.001

 Baseline

1.18 ± 0.27

1.17 ± 0.31

0.001

0.972

 Week 2

1.60 ± 0.40

1.19 ± 0.38

13.620

< 0.001

 Week 12

1.99 ± 0.56

1.20 ± 0.31

33.293

< 0.001

LD (mm)

0.15

0.700

 Baseline

70.58 ± 33.40

59.16 ± 40.55

0.914

0.343

 Week 2

63.51 ± 29.79

58.98 ± 38.33

0.125

0.725

 Week 12

48.07 ± 27.86

71.57 ± 46.37

6.044

0.017

T2WI-CNR

0.359

0.551

 Baseline

39.28 ± 22.62

30.32 ± 18.19

1.930

0.170

 Week 2

41.56 ± 24.22

37.43 ± 24.21

0.920

0.341

 Week 12

36.29 ± 23.41

40.82 ± 28.27

0.429

0.515

t/Z

P

Week 2

0.30 (−0.03, 1.38)

0.01(−0.29, 0.30)

− 4.819

< 0.001

Week 12

0.67 (−0.07, 3.13)

0.06 (− 0.26, 0.52)

−4.890

< 0.001

t/Z

P

 Week 2

−0.07 (− 0.36, 0.07)

−0.02 (− 0.12, 0.56)

−3.238

0.001

 Week 12

−0.28 (− 0.91, 0.08)

0.13 (− 0.07, 0.85)

− 6.120

< 0.001

t/Z

P

 Week 2

−0.03 (− 0.57, 2.11)

0.09 (− 0.36, 4.56)

−0.663

0.508

 Week 12

−0.04 (−1.10, 7.43)

0.28 (− 0.70, 2.88)

− 1.962

0.050