Fig. 9
![Fig. 9](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12885-018-4597-x/MediaObjects/12885_2018_4597_Fig9_HTML.png)
Immunolocalization of enzymes involved in the modification of CS chains. a-b Immunolocalization of chondroitin 4 sulfotransferase 2. a, Normal mucosa showing positive staining in crypts (arrow). b, Metastatic tumor showing a decrease in staining; magnification 40X. c-d, Immunolocalization of chondroitin 6 sulfotransferase 1. c, Normal mucosa, magnification 40X. d, Transition area between normal colon mucosa and tumor; the healthy tissue appears unmarked (asterisks), while the tumor shows intense immunoreactivity in the crypts (arrow), magnification 40X. e-f, Immunolocalization of uronyl-2-sulfotransferase. e, normal mucosa, (f), tumor, magnification 40X