Skip to main content

Table 3 Significance of the difference in MMP-8, −9, and TIMP-1 serum concentrations in 330 colorectal cancer patients

From: Serum MMP-8 and TIMP-1 predict prognosis in colorectal cancer

Clinicopathological variable MMP-8 MMP-9 TIMP-1
Median (IQR) P-value Median (IQR) P-value Median (IQR) P-value
Agea
  < =65 56 (36–97) 0.773 205 (136–287) 0.159 138 (123–162) < 0.001
  > 65 63 (32–125)   185 (123–265)   164 (141–196)  
Gendera
 Male 60 (32–122) 0.861 209 (141–299) 0.015 154 (135–185) 0.020
 Female 57 (35–112)   183 (105–254)   147 (123–177)  
Dukes classificationb
 A 50 (31–76) < 0.001 171 (95–269) 0.040 142 (122–163) 0.024
 B 55 (33–90)   194 (131–318)   153 (131–183)  
 C 51 (30–101)   183 (123–246)   152 (134–178)  
 D 137 (56–328)   223 (161–310)   166 (132–257)  
pTb
 pT1 50 (22–64) 0.004 237 (83–297) 0.113 144 (117–190) 0.028
 pT2 50 (27–90)   164 (101–244)   144 (126–166)  
 pT3 58 (34–129)   195 (128–287)   152 (131–179)  
 pT4 93 (58–265)   211 (165–284)   180 (148–244)  
pNb
 pN0 56 (33–93) 0.238 148 (127–175) 0.183 149 (127) 0.372
 pN1 64 (33–93)   154 (135–181)   154 (135–181)  
 pN2 63 (35–140)   160 (130–188)   160 (130–188)  
pMa
 pM0 54 (32–94) < 0.001 189 (121–265) 0.028 150 (131–175) 0.054
 pM1 118 (56–332)   221 (159–304)   165 (131–259)  
Grade (WHO)b
 1 66 (34–173) 0.227 204 (137–293) 0.717 166 (110–197) 0.727
 2 60 (33–113)   193 (116–273)   150 (131–179)  
 3 41 (27–78)   159 (136–299)   163 (137–182)  
 4 102 (36–185)   215 (183–273)   157 (126–189)  
Locationa
 Colon 65 (35–134) 0.104 204 (143–284) 0.116 157 (131–187) 0.053
 Rectum 54 (32–103)   185 (109–273)   148 (131–174)  
Sidea
 Right 70 (39–134) 0.038 208 (152–290) 0.266 161 (135 (191) 0.016
 Left 54 (32–104)   189 (120–273)   149 (130–175)  
Histologic typea
 Adeno 58 (33–120) 0.726 192 (125–274) 0.374 152 (131–182) 0.558
 Mucinous 63 (40–96)   221 (157–320)   156 (126–198)  
  1. Abbreviations: MMP matrix metalloproteinase, TIMP-1 tissue inhibitor of matrix metalloproteinase-1, IQR interquartile range
  2. aMann-Whitney U-test, bKruskal-Wallis test