Table 3 Significance of the difference in MMP-8, −9, and TIMP-1 serum concentrations in 330 colorectal cancer patients
From: Serum MMP-8 and TIMP-1 predict prognosis in colorectal cancer
Clinicopathological variable | MMP-8 | MMP-9 | TIMP-1 | |||
|---|---|---|---|---|---|---|
Median (IQR) | P-value | Median (IQR) | P-value | Median (IQR) | P-value | |
Agea | ||||||
< =65 | 56 (36–97) | 0.773 | 205 (136–287) | 0.159 | 138 (123–162) | < 0.001 |
> 65 | 63 (32–125) | 185 (123–265) | 164 (141–196) | |||
Gendera | ||||||
Male | 60 (32–122) | 0.861 | 209 (141–299) | 0.015 | 154 (135–185) | 0.020 |
Female | 57 (35–112) | 183 (105–254) | 147 (123–177) | |||
Dukes classificationb | ||||||
A | 50 (31–76) | < 0.001 | 171 (95–269) | 0.040 | 142 (122–163) | 0.024 |
B | 55 (33–90) | 194 (131–318) | 153 (131–183) | |||
C | 51 (30–101) | 183 (123–246) | 152 (134–178) | |||
D | 137 (56–328) | 223 (161–310) | 166 (132–257) | |||
pTb | ||||||
pT1 | 50 (22–64) | 0.004 | 237 (83–297) | 0.113 | 144 (117–190) | 0.028 |
pT2 | 50 (27–90) | 164 (101–244) | 144 (126–166) | |||
pT3 | 58 (34–129) | 195 (128–287) | 152 (131–179) | |||
pT4 | 93 (58–265) | 211 (165–284) | 180 (148–244) | |||
pNb | ||||||
pN0 | 56 (33–93) | 0.238 | 148 (127–175) | 0.183 | 149 (127) | 0.372 |
pN1 | 64 (33–93) | 154 (135–181) | 154 (135–181) | |||
pN2 | 63 (35–140) | 160 (130–188) | 160 (130–188) | |||
pMa | ||||||
pM0 | 54 (32–94) | < 0.001 | 189 (121–265) | 0.028 | 150 (131–175) | 0.054 |
pM1 | 118 (56–332) | 221 (159–304) | 165 (131–259) | |||
Grade (WHO)b | ||||||
1 | 66 (34–173) | 0.227 | 204 (137–293) | 0.717 | 166 (110–197) | 0.727 |
2 | 60 (33–113) | 193 (116–273) | 150 (131–179) | |||
3 | 41 (27–78) | 159 (136–299) | 163 (137–182) | |||
4 | 102 (36–185) | 215 (183–273) | 157 (126–189) | |||
Locationa | ||||||
Colon | 65 (35–134) | 0.104 | 204 (143–284) | 0.116 | 157 (131–187) | 0.053 |
Rectum | 54 (32–103) | 185 (109–273) | 148 (131–174) | |||
Sidea | ||||||
Right | 70 (39–134) | 0.038 | 208 (152–290) | 0.266 | 161 (135 (191) | 0.016 |
Left | 54 (32–104) | 189 (120–273) | 149 (130–175) | |||
Histologic typea | ||||||
Adeno | 58 (33–120) | 0.726 | 192 (125–274) | 0.374 | 152 (131–182) | 0.558 |
Mucinous | 63 (40–96) | 221 (157–320) | 156 (126–198) | |||