Fig. 4
From: WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage
WDR5 depletion increases DNA damage and reduces H3K4Me3. a Western blot of PARP, γH2AX, total H2AX, H3K4Me3, and H3K4Me1 following 96-h WDR5 knockdown or 72-h OICR-9429 treatment in colon cancer cells. b Percentage of cells within the sub-G1, G1, S, or G2 phase based on propidium iodide staining and flow cytometry analysis following WDR5 depletion for 72 h or 10 μM OICR-9429 treatment for 48 h in three colon cancer cell lines