Fig. 2From: Pancreatic cancer as a sentinel for hereditary cancer predispositionProportion of carriers of pathogenic variants and high probability of pathogenicity variants of uncertain significance (HiP-VUS) in unselected pancreatic cancer. Results based on a meta-analysis of the unselected pancreatic cancer cases from the Huntsman Cancer Hospital (HCH), the Mayo Clinic, and the pancreatic cancer cases from The Cancer Genome Atlas (TCGA). Carrier frequency point estimates and 95% confidence intervals for groups of genes are presented on a log-scale. A list of genes contained within each analysis group is provided in Additional file 1: Table S1. The breakdown of results by study is described in Additional file 1: Table S3. HBOC = Hereditary Breast and Ovarian Cancer; HRR = Homologous Recombination and Repair; ICR = Interstrand Crosslink Repair; OC = Ovarian Cancer; BC = Breast CancerBack to article page