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Table 1 Clinical information of patients with IgD MM before chemotherapy

From: Detection of intracellular IgD using flow cytometry could be a novel and supplementary method to diagnose IgD multiple myeloma

Patient No
Items
1 2 3 4 5
Age 75 68 45 55 62
Sex Male Male Male Female Male
Durie-Salmon staging system IIIA IIIB IIIA IIIA IIIB
International staging system III III II III III
RISS stage III II II II II
Extramedullary involvement The liver is involved None None None Pulmonary involvement
Multiple lytic bone lesions (X-ray) None None Positive Positive Positive
BM sample of Congo red Staining Negative Negative Negative Negative Negative
BM biopsy Involvement of MM cells Diffuse Diffuse Focal Diffuse Diffuse
Percentage of plasma cells in BM (Morphology) 73.5% 60.5% 46.5% 72.5% 35.5%
Percentage of plasma cells in BM (Flow cytometry) 12.9%a 8.2%a 4.1%a 3.3%a 0.4%
Chromosomal study Complex chromosomal Abnormalities 45, X, -Y Normal 46, XX, inv(9)(p12q13) Complex chromosomal abnormalities
FISH t(11;14) Normal Normal Normal t(11;14)
CBC      
 WBC (× 109/L) 3.57 6.54 3.86 3.52 10.63
 HGB (g/dL) 2.7 7.0 8.3 11.9 8.3
 PLT (×109/L) 59 138 101 213 242
LDH (U/L) (100~ 250) 291 231 177 180 217
Serum calcium Low Low Normal Normal Normal
Albumin (g/dL) 38 30 43 42 40
Serum β2 micoglobulin (mg/L) 11.39 27.63 4.06 7.40 10.14
Serum creatinine mg/dL 1.4 8.2 0.9 1.1 2.0
Serum Ig (mg/dL)      
 IgD 364 Traceb 653 1063 394
 IgA 16.3 35.7 15.5 4.87 21.4
 IgG 523 545 427 1110 618
 IgM 9.4 10.4 5.1 72.8 22
Serum light chain type Lambda Lambda Lambda Lambda Lambda
Urine M protein (g/day) 5.80 0.31 6.25 3.95 0
Overall survival (month) 6 4 31 13 39
Living state Dead Dead Alive Dead Alive
  1. aFlow cytometry analysis was performed to these patients after chemotherapy
  2. bThe IgD was too low to detect. The serum IgD of this patient was detected after four cycles of chemotherapy
  3. BM bone marrow, MM multiple myeloma, Ig immunoglobulin, CBC complete blood count, M protein, monoclonal protein