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Table 1 Recent case reports in which antimyeloma drugs have been applied in HIV-negative PBL patients

From: A patient with plasmablastic lymphoma achieving long-term complete remission after thalidomide-dexamethasone induction and double autologous stem cell transplantation: a case report

Agent

Author, year

Combination

Patients

Setting

Outcomes

Bortezomib

Saba, 2013 [8]

Single agent

1

Salvage

PR; DOR 5 months; death

Yan, 2014 [9]

Bor + Rituximab + Dex

1

Salvage

nCR; 3+ months post-ASCT

Castillo, 2015 [10]

Bor + DA-EPOCH

3 (*)

First-line

3 CR; DOR 12+, 18+, 24+ months

Hirosawa, 2015 [11]

Single agent

1

Salvage

Transient regression

Fedele, 2016 [12]

Bor + DA-EPOCH

1

First-line

CR; DOR 24+ months

Cencini, 2016 [13]

Bor + COMP

1

First-line

CR; DOR 12 months

Lenalidomide

Carras, 2015 [14]

Single agent

1

Salvage

CR; DOR 6 months

Schmit, 2017 [15]

Len + cyclo + dex

1

First-line

CR; DOR 24+ months

  1. (*) 2 HIV-positive patients included
  2. Bor bortezomib, Dex dexamethasone, DA-EPOCH dose-adjusted EPOCH, COMP same as CHOP, but with liposomal doxorubicin, Len lenalidomide, Cyclo cyclophosphamide. PR partial response, (n)CR (near) complete response, DOR duration of response, ASCT autologous transplantation. The sign “+” indicates an ongoing response at the moment of the report