Table 4 Most common adverse events by CTCAE grade (incidence of all grades: ≥ 15%)
Adverse events | Severity, n (%) | |||
|---|---|---|---|---|
All grades | Grade 1 | Grade 2 | Grade 3 | |
Hematologic | ||||
PB regimen (n = 51) | ||||
Anemia | 30 (58.8) | 18 (35.3) | 9 (17.6) | 3 (5.9) |
Leukopenia | 21 (41.2) | 10 (19.6) | 8 (15.7) | 3 (5.9) |
Neutropenia | 19 (37.3) | 2 (3.9) | 9 (17.6) | 8 (15.7) |
Eribulin maintenance therapy (n = 45) | ||||
Anemia | 26 (57.8) | 21 (46.7) | 4 (8.9) | 1 (2.2) |
Leukopenia | 24 (53.3) | 9 (20.0) | 10 (22.2) | 5 (11.1) |
Neutropenia | 23 (51.1) | 2 (4.4) | 12 (26.7) | 9 (20.0) |
Nonhematologic | ||||
PB regimen (n = 51) | ||||
Alopecia | 51 (100.0) | 2 (3.9) | 49 (96.1) | – |
Peripheral sensory neuropathy | 37 (72.5) | 28 (54.9) | 8 (15.7) | 1 (2.0) |
Increased AST | 15 (29.4) | 13 (25.5) | 1 (2.0) | 1 (2.0) |
Dysgeusia | 15 (29.4) | 15 (29.4) | 0 (0.0) | – |
Epistaxis | 15 (29.4) | 15 (29.4) | 0 (0.0) | 0 (0.0) |
Fatigue | 12 (23.5) | 10 (19.6) | 2 (3.9) | 0 (0.0) |
Arthralgia | 12 (23.5) | 12 (23.5) | 0 (0.0) | 0 (0.0) |
Rash | 12 (23.5) | 12 (23.5) | 0 (0.0) | 0 (0.0) |
Increased ALT | 10 (19.6) | 8 (15.7) | 2 (3.9) | 0 (0.0) |
Anorexia | 10 (19.6) | 7 (13.7) | 3 (5.9) | 0 (0.0) |
Nail discoloration | 10 (19.6) | 10 (19.6) | – | – |
Peripheral motor neuropathy | 9 (17.6) | 8 (15.7) | 0 (0.0) | 0 (0.0) |
Myalgia | 8 (15.7) | 8 (15.7) | 0 (0.0) | 0 (0.0) |
Eribulin maintenance therapy (n = 45) | ||||
Peripheral sensory neuropathy | 37 (82.2) | 18 (40.0) | 17 (37.8) | 2 (4.4) |
Increased AST | 25 (55.6) | 21 (46.7) | 3 (6.7) | 1 (2.2) |
Dysgeusia | 16 (35.6) | 13 (28.9) | 3 (6.7) | – |
Increased ALT | 16 (35.6) | 14 (31.1) | 2 (4.4) | 0 (0.0) |
Alopecia | 15 (33.3) | 8 (17.8) | 7 (15.6) | – |
Fatigue | 14 (31.1) | 10 (22.2) | 4 (8.9) | 0 (0.0) |
Anorexia | 14 (31.1) | 11 (24.4) | 3 (6.7) | 0 (0.0) |
Peripheral motor neuropathy | 13 (28.9) | 10 (22.2) | 3 (6.7) | 0 (0.0) |
Increased creatinine | 13 (28.9) | 12 (26.7) | 1 (2.2) | 0 (0.0) |
Nausea | 11 (24.4) | 11 (24.4) | 0 (0.0) | 0 (0.0) |
Arthralgia | 10 (22.2) | 9 (20.0) | 1 (2.2) | 0 (0.0) |
Myalgia | 9 (20.0) | 7 (15.6) | 2 (4.4) | 0 (0.0) |
Nail loss | 9 (20.0) | 4 (8.9) | 5 (11.1) | – |
Constipation | 8 (17.8) | 5 (11.1) | 3 (6.7) | 0 (0.0) |
Epistaxis | 7 (15.6) | 7 (15.6) | 0 (0.0) | 0 (0.0) |
Nail discoloration | 7 (15.6) | 7 (15.6) | – | – |