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Table 1 Clinical and laboratory features of the subjects included in the study

From: A rare CHD5 haplotype and its interactions with environmental factors predicting hepatocellular carcinoma risk

Characteristics Discovery study Replication study Combined study
Cases (%) Controls (%) P Cases (%) Controls (%) P Cases (%) Controls (%) P
n 280 255   549 510   829 765  
Age (ys, mean ± SD) 55.1 ± 14.6 41.5 ± 9.1 < 0.001a 56.6 ± 11.3 47.2 ± 10.7 < 0.001a 56.0 ± 13.6 44.8 ± 10.3 < 0.001a
Gender (F/M) 53/227 91/164 < 0.001b 125/424 167/343 < 0.001b 178/651 258/507 < 0.001b
Smoking 99 (35.36) 56 (21.96) 0.001b 231 (42.08) 145 (28.43) < 0.001b 330 (39.81) 201 (26.27) < 0.001b
 Missing 5 (1.79) 7 (2.75)   22 (4.01) 26 (5.10)   27 (3.26) 33 (3.98)  
Drinking 95 (33.93) 54 (21.18) 0.001b 210 (38.25) 129 (25.29) < 0.001b 305 (36.79) 183 (23.92) < 0.001b
 Missing 8 (2.86) 7 (2.75)   28 (5.10) 29 (5.69)   36 (4.34) 36 (4.71)  
HBsAg+ 224 (80.00) 0 (0.00)   419 (76.32) 0 (0.00)   643 (77.56)   
Anti-HCV 0 (0.00) 0 (0.00)   4 (0.73) 0 (0.00)   4 (0.48) 0 (0.00)  
Anti-HIV 0 (0.00) 0 (0.00)   2 (0.36) 0 (0.00)   2 (0.24) 0 (0.00)  
Serum AFP (>25 μg/L) 233 (83.21) 0 (0.00)   431 (78.51) 0 (0.00)   664 (80.10) 0 (0.00)  
Tumor size (cm)
 ≤5 65 (23.21)    139 (25.32)    204 (24.61)   
 >5, ≤10 93 (33.21)    273 (49.73)    366 (44.15)   
 >10 122 (43.57)    137 (24.95)    259 (31.24)   
Cirrhosis
 No 16 (5.71)    38 (6.92)    54 (6.51)   
 Yes 260 (92.86)    504 (91.80)    764 (92.16)   
 Missing 4 (1.43)    7 (1.28)    11 (1.33)   
Tumor morphology
 No residual tumor 19 (6.79)    43 (7.83)    62 (7.48)   
 Uninodular tumor 55 (19.64)    89 (16.21)    144 (17.37)   
 Multinodular tumor 107 (38.21)    228 (41.53)    335 (40.41)   
 Massive tumor 92 (32.86)    168 (30.60)    260 (31.36)   
 Missing 7 (2.50)    21 (3.83)    28 (3.38)   
Differentiation
 Well 31 (11.07)    77 (14.03)    108 (13.03)   
 Moderate 78 (27.86)    195 (35.52)    273 (32.93)   
 Poor 171 (61.07)    277 (50.46)    448 (54.04)   
Metastasis
 Abscent 81 (28.93)    189 (34.43)    270 (32.57)   
 Present 193 (68.93)    347 (63.21)    540 (65.14)   
 Missing 6 (2.14)    13 (2.37)    19 (2.29)   
TNM stage
 I 53 (18.93)    148 (26.96)    201 (24.25)   
 II 95 (33.93)    230 (41.89)    325 (39.20)   
 III 64 (22.86)    110 (20.04)    174 (20.99)   
 IV 68 (24.29)    61 (11.11)    129 (15.56)   
  1. F females, M males, SD standard deviation, AFP alpha fetoprotein, TNM tumor, nodes, metastasis-classification
  2. aKruskal-Wallis test for continuous variables
  3. bChi square test for categorical variables