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Table 3 Hazard ratios of breast cancer across tertiles of BMI by clusters of breast tumors from hierarchical clustering (see Fig. 1)a

From: Obesity as risk factor for subtypes of breast cancer: results from a prospective cohort study

 

Postmenopausal non-users of HTb

Postmenopausal users of HTb

Pre- and perimenopausal womenb

 

Cases (n)

HR

CI (95%)

 

Cases (n)

HR

CI (95%)

 

Cases (n)

HR

CI (95%)

Cluster 1

Tertile 1

4

1

 

Tertile 1

30

1

 

Tertile 1

59

1

 

(ER+, PR+, HER2-, Ki67 low , bcl-2+, and p53-)

Tertile 2

8

1.02

(0.31,3.40)

Tertile 2

32

0.74

(0.44,1.22)

Tertile 2

31

0.64

(0.41,1.00)

Tertile 3

33

2.50

(0.86,7.23)

Tertile 3

24

0.61

(0.35,1.06)

Tertile 3

21

0.55

(0.33,0.93)

Per 5 kg/m 2

 

1.44

(1.10,1.90)

Per 5 kg/m 2

 

0.68

(0.50,0.94)

Per 5 kg/m 2

 

0.85

(0.67,1.08)

p trend

 

0.009

 

p trend

 

0.018

 

p trend

 

0.19

 

Cluster 2

Tertile 1

5

1

 

Tertile 1

10

1

 

Tertile 1

18

1

 

(ER- or ER+ that are Bcl-2-)

Tertile 2

6

0.77

(0.23,2.56)

Tertile 2

18

1.14

(0.52,2.53)

Tertile 2

9

0.59

(0.26,1.32)

Tertile 3

16

1.40

(0.49,4.04)

Tertile 3

6

0.43

(0.15,1.21)

Tertile 3

20

1.52

(0.77,3.00)

Per 5 kg/m 2

 

1.15

(0.78,1.70)

Per 5 kg/m 2

 

0.83

(0.52,1.32)

Per 5 kg/m 2

 

1.22

(0.91,1.62)

p trend

 

0.47

 

p trend

 

0.42

 

p trend

 

0.18

 

Cluster 3

Tertile 1

5

1

 

Tertile 1

20

1

 

Tertile 1

48

1

 

(ER+ with at least one other marker indicative of higher aggressiveness)

Tertile 2

21

2.98

(1.01,8.75)

Tertile 2

33

1.20

(0.68,2.12)

Tertile 2

26

0.72

(0.44,1.18)

Tertile 3

16

1.57

(0.51,4.83)

Tertile 3

17

0.77

(0.39,1.51)

Tertile 3

31

1.13

(0.70,1.82)

Per 5 kg/m 2

 

1.00

(0.71,1.42)

Per 5 kg/m 2

 

0.82

(0.58,1.15)

Per 5 kg/m 2

 

0.94

(0.74,1.19)

p trend

 

0.99

 

p trend

 

0.24

 

p trend

 

0.60

 
  1. Median (p25, p75) values of BMI: Tertile 1: 21.4 (20.4, 22.3), Tertile 2: 24.8 (23.9, 25.7); Tertile 3: 29.9 (28.1, 32.7)
  2. No statistical heterogeneity of HRs across subtypes was observed
  3. aFrom Cox regression models adjusted for height, number of full-term pregnancies, pill use, education level, smoking status, and study center bAt baseline (HT hormone therapy)
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BMC Cancer

ISSN: 1471-2407

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