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Table 3 Annual percent change in age and sex-standardized incidence rates of primary CNS tumors (reference: French National Census 2000–2012) according to sex, age, histology, malignancy status and urban/rural place of residence, Gironde CNS registry, 2000–2012

From: Increasing incidence of central nervous system (CNS) tumors (2000–2012): findings from a population based registry in Gironde (France)

  n period APC 95% CI, APC Trend P-value
All CNS Tumorsa 3515 2000–2012 + 2.7 (+ 1.8; + 3.7) < 0.0001
 Sex
  Male 1526 2000–2012 + 1.8 (+ 0.3; + 3.3) 0.006
  Female 1989 2000–2012 + 3.6 (+ 2.2; + 5.0) < 0.0001
 Age
  0–24 y 254 2000–2012 + 0.6 (−2.5; + 3.8) 0.7
  25–49 y 730 2000–2012 + 1.2 (− 0.9; + 3.4) 0.2
  50–64 y 1088 2000–2012 + 1.2 (− 0.6; + 3.1) 0.2
  65–79 y 1000 2000–2012 + 3.0 (+ 0.8; + 5.2) 0.002
  80 y and overb 443 2000–2002 + 62 (+ 27; + 108) < 0.0001
   2002–2012 + 1.4 (− 2.4; + 5.4) 0.4
 Place of residence
  Urban 2835 2000–2012 + 2.4 (+ 1.6; + 3.2) < 0.0001
  Rural 680 2000–2012 + 4.0 (+ 1.4; + 6.8) 0.0008
 Histological confirmation
  Yes 2706 2000–2012 + 2.1 (+ 1.1; + 3.2) < 0.0001
  No 809 2000–2012 + 4.8 (+ 2.8; + 6.9) < 0.0001
Malignant tumors(/3) 1548 2000–2012 + 1.3 (− 0.20; + 2.8) 0.06
 Sex
  Male 860 2000–2012 + 0.99 (− 0.82; + 2.8) 0.2
  Female 688 2000–2012 + 1.7 (−0.42; + 3.9) 0.1
 Age
  0–24 y 122 2000–2012 + 0.90 (− 3.5; + 5.5) 0.6
  25–49 y 268 2000–2012 − 1.2 (− 5.9; + 3.7) 0.6
  50–64 y 457 2000–2012 + 1.4 (− 1.3; + 4.2) 0.2
  65–79 y 513 2000–2012 + 1.3 (−1.4; + 4.0) 0.3
  80 y and over 188 2000–2012 + 2.0 (−4.0; + 8.4) 0.5
Non-malignant tumors (/1, /0) 1967 2000–2012 + 4.0 (+ 2.7 − + 5.3) < 0.0001
 Sex
  Male 666 2000–2012 + 3.1 (+ 0.35; + 5.8) 0.01
  Female 1301 2000–2012 + 4.6 (+ 2.6; + 6.7) < 0.0001
 Age
  0–24 y 132 2000–2012 + 0.53 (−3.3; + 4.5) 0.8
  25–49 y 462 2000–2012 + 2.8 (+ 0.35; + 5.3) 0.01
  50–64 y 631 2000–2012 + 1.3 (−1.3; + 3.9) 0.3
  65–79 y 487 2000–2012 + 4.8 (+ 2.3; + 7.4) < 0.0001
  80 y and overb 255 2000–2002 + 103 (+ 5.1; + 292) 0.01
   2002–2012 + 4.5 (−0.70; + 10) 0.05
Neuroepithelial tumors 1496 2000–2012 + 1.5 (−0.34; + 3.5) 0.1
 Sex
  Male 843 2000–2012 + 1.5 (−0.64; + 3.6) 0.1
  Female 653 2000–2012 + 1.6 (−0.54; + 3.9) 0.1
 Age      
  0–24 y 179 2000–2012 + 1.3 (−3.8; + 6.6) 0.6
  25–49 y 278 2000–2012 −1.1 (−5.9; + 4.0) 0.6
  50–64 y 430 2000–2012 + 1.6 (−0.95; + 4.2) 0.2
  65–79 y 458 2000–2012 + 1.5 (−1.5; + 4.6) 0.3
  80 y and over 151 2000–2012 + 3.7 (−1.9; + 9.7) 0.1
Meningeal tumors 1321 2000–2012 + 5.4 (+ 3.8; + 7.0) < 0.0001
 Sex
  Male 346 2000–2012 + 6.1 (+ 0.82; + 11) 0.01
  Female 975 2000–2012 + 5.6 (+ 3.4; + 7.8) < 0.0001
 Age
  0–24 y 24 2000–2012    
  25–49 y 258 2000–2012 + 4.2 (+ 0.75; + 7.8) 0.007
  50–64 y 445 2000–2012 + 1.5 (−1.1; + 4.2) 0.2
  65–79 y 375 2000–2012 + 5.8 (+ 2.5; + 9.2) < 0.0001
  80 y and over 219 2000–2012 + 11 (+ 5.1; + 17) < 0.0001
Other histological subtypes
  Cranial and spinal nerve tumors 422 2000–2012 + 0.68 (−0.75; + 2.1) 0.3
  Lymphomas 115 2000–2012 + 3.6 (−3.5; + 11) 0.3
  Other tumorsc 161 2000–2012 − 1.2 (−6.6; + 4.5) 0.6
  1. CI confidence interval, APC annual percent change
  2. aPituitary tumors, tumors associated with AIDS, recurrence of tumors, and metastatic tumors were not included in the registry
  3. bThe joinpoint analysis identified two trends for individuals 80 years and over: 2000–2002 and 2002–2012
  4. cOther tumors included germ cell tumors, tumors of the sellar region and unclassified tumors