Table 3 Univariate and multivariate Cox proportional hazard analyses of clinicopathologic variables for overall and disease-free survival in oral cavity SCC patients

Age

(> 60 yr. vs ≤ 60 yr)

2.25 (1.24–4.11)

0.008*

3.01 (1.38–6.56)

0.006*

Gender

(male vs female)

1.02 (0.55–1.88)

0.949

0.89 (0.43–1.84)

0.748

Smoking status ^a

(ex & current vs never)

0.56 (0.28–1.13)

0.104

0.37 (0.17–0.82)

0.014*

Tumour grade ^b

(3 vs 1&2)

2.32 (1.24–4.32)

0.008*

2.29 (1–5.26)

0.051

T stage

(3&4 vs 1&2)

1.68 (0.92–3.09)

0.093

1.49 (0.7–3.16)

0.301

N stage

(2&3 vs 0&1)

1.46 (0.78–2.73)

0.243

1.97 (0.77–5.05)

0.158

LC3B expression

(high vs low)

1.83 (1–3.37)

0.051

1.67 (0.78–3.58)

0.19

Age

(> 60 yr. vs ≤ 60 yr)

1.69 (0.86–3.35)

0.13

1.49 (0.63–3.49)

0.361

Gender

(male vs female)

0.9 (0.45–1.8)

0.767

0.77 (0.33–1.82)

0.553

Smoking status ^a

(ex & current vs never)

0.93 (0.38–2.27)

0.867

0.68 (0.26–1.82)

0.446

Tumour grade ^b

(3 vs 1&2)

1.82 (0.87–3.83)

0.114

2.16 (0.79–5.91)

0.132

T stage

(3&4 vs 1&2)

1.09 (0.51–2.36)

0.82

0.81 (0.33–2)

0.643

N stage

(2&3 vs 0&1)

2.07 (1.02–4.22)

0.045*

3.42 (1.21–9.67)

0.021*

LC3B expression

(high vs low)

2.36 (1.19–4.67)

0.014*

1.82 (0.83–4)

0.138