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Table 3 Univariate and multivariate Cox proportional hazard analyses of clinicopathologic variables for overall and disease-free survival in oral cavity SCC patients

From: Differences in LC3B expression and prognostic implications in oropharyngeal and oral cavity squamous cell carcinoma patients

Oral cavity SCC   
Variable Univariate analysis Multivariate analysis
Hazard ratio (95% Cl) P value Hazard ratio (95% Cl) P value
3A. Overall survival
Age
(> 60 yr. vs ≤ 60 yr)
2.25 (1.24–4.11) 0.008* 3.01 (1.38–6.56) 0.006*
Gender
(male vs female)
1.02 (0.55–1.88) 0.949 0.89 (0.43–1.84) 0.748
Smoking status a
(ex & current vs never)
0.56 (0.28–1.13) 0.104 0.37 (0.17–0.82) 0.014*
Tumour grade b
(3 vs 1&2)
2.32 (1.24–4.32) 0.008* 2.29 (1–5.26) 0.051
T stage
(3&4 vs 1&2)
1.68 (0.92–3.09) 0.093 1.49 (0.7–3.16) 0.301
N stage
(2&3 vs 0&1)
1.46 (0.78–2.73) 0.243 1.97 (0.77–5.05) 0.158
LC3B expression
(high vs low)
1.83 (1–3.37) 0.051 1.67 (0.78–3.58) 0.19
3B. Disease-free survival
Age
(> 60 yr. vs ≤ 60 yr)
1.69 (0.86–3.35) 0.13 1.49 (0.63–3.49) 0.361
Gender
(male vs female)
0.9 (0.45–1.8) 0.767 0.77 (0.33–1.82) 0.553
Smoking status a
(ex & current vs never)
0.93 (0.38–2.27) 0.867 0.68 (0.26–1.82) 0.446
Tumour grade b
(3 vs 1&2)
1.82 (0.87–3.83) 0.114 2.16 (0.79–5.91) 0.132
T stage
(3&4 vs 1&2)
1.09 (0.51–2.36) 0.82 0.81 (0.33–2) 0.643
N stage
(2&3 vs 0&1)
2.07 (1.02–4.22) 0.045* 3.42 (1.21–9.67) 0.021*
LC3B expression
(high vs low)
2.36 (1.19–4.67) 0.014* 1.82 (0.83–4) 0.138
  1. a= missing 9 cases
  2. b= missing 2 cases
  3. *= statistical significance (p < 0.05)