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Table 2 Univariate and multivariate Cox proportional hazard analyses of clinicopathologic variables for overall and disease-free survival in oropharyngeal SCC patients

From: Differences in LC3B expression and prognostic implications in oropharyngeal and oral cavity squamous cell carcinoma patients

Oropharyngeal SCC
Variable Univariate analysis   Multivariate analysis
Hazard ratio (95% Cl) P value   Hazard ratio (95% Cl) P value
2A. Overall survival
Age
(> 60 yr. vs ≤ 60 yr)
2.13 (0.96–4.72) 0.062   2.55 (0.86–7.58) 0.093
Gender
(male vs female)
0.64 (0.25–1.69) 0.372   0.23 (0.07–0.76) 0.016*
Smoking status a
(ex & current vs never)
1.49 (0.2–11.23) 0.697   0.64 (0.07–5.68) 0.691
Tumour grade b
(3 vs 1&2)
0.69 (0.27–1.81) 0.456   0.23 (0.07–0.78) 0.018*
T stage
(3&4 vs 1&2)
1.51 (0.69–3.31) 0.307   0.27 (0.07–1.03) 0.055
N stage
(2&3 vs 0&1)
1.39 (0.64–3.05) 0.407   5.21 (1.43–19.01) 0.012*
LC3B expression
(high vs low)
3.18 (1.31–7.71) 0.01*   4.02 (1.38–11.74) 0.011*
2B. Disease-free survival
Age
(> 60 yr. vs ≤ 60 yr)
3.9 (1.35–11.26) 0.012*   3.24 (0.89–11.81) 0.075
Gender
(male vs female)
0.75 (0.24–2.39) 0.631   0.5 (0.11–2.35) 0.379
Smoking status a
(ex & current vs never)
NC NC   NC NC
Tumour grade b
(3 vs 1&2)
0.61 (0.19–1.98) 0.409   0.39 (0.09–1.78) 0.226
T stage
(3&4 vs 1&2)
1.46 (0.55–3.91) 0.447   0.53 (0.13–2.14) 0.372
N stage
(2&3 vs 0&1)
1.21 (0.45–3.26) 0.705   2.33 (0.57–9.49) 0.237
LC3B expression
(high vs low)
2.49 (0.87–7.09) 0.088   1.91 (0.57–6.36) 0.293
  1. a= missing 2 cases
  2. b= missing 4 cases
  3. *= statistical significance (p < 0.05)
  4. NC = not calculated (coefficient cannot be estimated due to imbalance data)