Fig. 7
From: Dynamic Hyaluronan drives liver endothelial cells towards angiogenesis
Schematic diagram showing influence of HA on angiogenesis in liver ECs. In the liver microenvironment the sinusoidal pericyte, hepatic stellate cells (HSCs) synthesize HA and this compound degraded by the sinusoidal ECs via the process of endocytosis [16]. Elevated HA level or administration of HA are co-ordinate with expression of HABP1 and internalization of β- catenin in ECs. HA treatment enhanced the tubular sprout formation, rearrangement of the actin cytoskeleton, cell migration and adhesion along with overexpression of angiogenic factors VEGFA and VEGFR1 in liver ECs